Stable Polymer Micelles Formed by Metal Coordination

Junyou Wang; Martien A. Cohen Stuart; Antonius T. M. Marcelis; Mathieu Colomb-Delsuc; Sijbren Otto; Jasper van der Gucht

doi:10.1021/ma301323z

Stable Polymer Micelles Formed by Metal Coordination

Junyou Wang^*, Martien A. Cohen Stuart, Antonius T. M. Marcelis, Mathieu Colomb-Delsuc, Sijbren Otto, Jasper van der Gucht

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

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Abstract

Metal-containing polymer micelles have attracted much attention due to their potential for medical and nanotechnological applications. In this paper, we present a method to prepare stable metal-containing polymer micelles. A diblock copolymer poly(4-vinylpyridine)-b-poly(ethylene oxide) (P4VP(48)-b-PEO193) with terdendate ligand groups grafted to the PVP block is synthesized. Added metal ions cross-link the ligand-carrying blocks together, while the hydrophilic block stabilizes the formed coordination complex, leading to the formation of micelles. The structure and stability of the formed micelles are investigated by light scattering and cyro-TEM. The strong coordination bonds provide high stability of the micelles: adding salt or EDTA hardly affects the formed micelles.

Original language	English
Pages (from-to)	7179-7185
Number of pages	7
Journal	Macromolecules
Volume	45
Issue number	17
DOIs	https://doi.org/10.1021/ma301323z
Publication status	Published - 11-Sept-2012

Keywords

COACERVATE CORE MICELLES
BLOCK-COPOLYMER MICELLES
INTEGRAL-EQUATIONS
COMPLEX
NANOPARTICLES
STABILITY
DIBLOCK
BINDING
LIGAND
IONS

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title = "Stable Polymer Micelles Formed by Metal Coordination",

abstract = "Metal-containing polymer micelles have attracted much attention due to their potential for medical and nanotechnological applications. In this paper, we present a method to prepare stable metal-containing polymer micelles. A diblock copolymer poly(4-vinylpyridine)-b-poly(ethylene oxide) (P4VP(48)-b-PEO193) with terdendate ligand groups grafted to the PVP block is synthesized. Added metal ions cross-link the ligand-carrying blocks together, while the hydrophilic block stabilizes the formed coordination complex, leading to the formation of micelles. The structure and stability of the formed micelles are investigated by light scattering and cyro-TEM. The strong coordination bonds provide high stability of the micelles: adding salt or EDTA hardly affects the formed micelles.",

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author = "Junyou Wang and Stuart, {Martien A. Cohen} and Marcelis, {Antonius T. M.} and Mathieu Colomb-Delsuc and Sijbren Otto and {van der Gucht}, Jasper",

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AU - Wang, Junyou

AU - Stuart, Martien A. Cohen

AU - Marcelis, Antonius T. M.

AU - Colomb-Delsuc, Mathieu

AU - Otto, Sijbren

AU - van der Gucht, Jasper

N1 - PT: J; TC: 0; UT: WOS:000309014000046

PY - 2012/9/11

Y1 - 2012/9/11

N2 - Metal-containing polymer micelles have attracted much attention due to their potential for medical and nanotechnological applications. In this paper, we present a method to prepare stable metal-containing polymer micelles. A diblock copolymer poly(4-vinylpyridine)-b-poly(ethylene oxide) (P4VP(48)-b-PEO193) with terdendate ligand groups grafted to the PVP block is synthesized. Added metal ions cross-link the ligand-carrying blocks together, while the hydrophilic block stabilizes the formed coordination complex, leading to the formation of micelles. The structure and stability of the formed micelles are investigated by light scattering and cyro-TEM. The strong coordination bonds provide high stability of the micelles: adding salt or EDTA hardly affects the formed micelles.

AB - Metal-containing polymer micelles have attracted much attention due to their potential for medical and nanotechnological applications. In this paper, we present a method to prepare stable metal-containing polymer micelles. A diblock copolymer poly(4-vinylpyridine)-b-poly(ethylene oxide) (P4VP(48)-b-PEO193) with terdendate ligand groups grafted to the PVP block is synthesized. Added metal ions cross-link the ligand-carrying blocks together, while the hydrophilic block stabilizes the formed coordination complex, leading to the formation of micelles. The structure and stability of the formed micelles are investigated by light scattering and cyro-TEM. The strong coordination bonds provide high stability of the micelles: adding salt or EDTA hardly affects the formed micelles.

KW - COACERVATE CORE MICELLES

KW - BLOCK-COPOLYMER MICELLES

KW - INTEGRAL-EQUATIONS

KW - COMPLEX

KW - NANOPARTICLES

KW - STABILITY

KW - DIBLOCK

KW - BINDING

KW - LIGAND

KW - IONS

U2 - 10.1021/ma301323z

DO - 10.1021/ma301323z

M3 - Article

SN - 0024-9297

VL - 45

SP - 7179

EP - 7185

JO - Macromolecules

JF - Macromolecules

IS - 17

ER -

Stable Polymer Micelles Formed by Metal Coordination

Abstract

Keywords

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