Staging(18)F-FDG PET/CT influences the treatment plan in melanoma patients with satellite or in-transit metastases

Lodewijka H. J. Holtkamp*, Annette H. Chakera, Sebastian Fung, Jonathan R. Stretch, Robyn P. M. Saw, Kenneth Lee, Sydney Ch'ng, Maria Gonzalez, John F. Thompson, Louise Emmett, Omgo E. Nieweg

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Whole-body positron emission tomography/computed tomography (PET/CT) and brain magnetic resonance imaging (MRI) are commonly used to stage patients with palpable lymph node metastases from melanoma, but their role in patients with satellite and/or in-transit metastasis (S&ITM) is unclear. The aim of this study was to establish the diagnostic value of PET/CT and brain MRI in these patients, and to assess their influence on subsequent management decisions. In this prospective study, 25 melanoma patients with a first presentation of S&ITM who had no clinical evidence of palpable nodal or distant metastasis underwent whole-body(18)F-FDG PET/CT and brain MRI after a tentative pre-scan treatment plan had been made. Sensitivity and specificity of imaging were determined by pathological confirmation, clinical outcome and repeat PET/CT and MRI at 6 months. PET/CT led to a modification of the initial treatment plan in four patients (16%). All four were upstaged (AJCC stage eighth edition). PET/CT was false-positive in one patient, who had a Schwannoma in his trapezius muscle. A thyroid carcinoma was an incidental finding in another patient. The sensitivity of PET/CT was 58% and specificity 83%. In 6 months following the baseline PET/CT, further sites of in-transit or systemic disease were identified in 10 patients (40%). Brain MRI did not alter the treatment plan or change the disease stage in any patient. Whole-body PET/CT improved staging in melanoma patients with S&ITM and changed the originally-contemplated treatment plan in 16%. MRI of the brain appeared not to be useful.

    Original languageEnglish
    Pages (from-to)358-363
    Number of pages6
    JournalMelanoma Research
    Issue number4
    Publication statusPublished - Aug-2020


    • fluorine-18-fluorodeoxyglucose positron emission tomography
    • computed tomography
    • in-transit
    • melanoma
    • MRI
    • satellites
    • staging

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