Standard of hygiene and immune adaptation in newborn infants

Henna Kallionpaa, Essi Laajala, Viveka Oling, Taina Harkonen, Vallo Tillmann, Natalya V. Dorshakova, Jorma Ilonen, Harri Landesmaki, Mikael Knip, Riitta Lahesmaa*, Katriina Koski, Matti Koski, Samppa Ryhanen, Heli Siljander, Anu-Maaria Hamalainen, Anne Ormisson, Aleksandr Peet, Valentina Ulich, Elena Kuzmicheva, Sergei MokurovSvettana Markova, Svetlana Pylova, Marina Isakova, Elena Shakurova, Vladimir Petrov, Tatyana Karapetyan, Tatyana Varlamova, Jorma Ilonen, Minna Kiviniemi, Kristi Alnek, Helis Janson, Raivo Uibo, Tiit Salum, Erika von Mutius, Juliane Weber, Helena Ahlfors, Robert Moulder, Janne Nieminen, Terhi Ruohtula, Outi Vaarala, Hanna Honkanen, Heikki Hyoty, Anita Kondrashova, Sami Oikarinen, Hermie J. M. Harmsen, Marcus C. De Goffau, Gjalt Welling, Kirsi Alahuhta, Tuuli Korhonen, Suvi M. Virtanen, DIABIMMUNE Study Grp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu. (C) 2014 The Authors. Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)136-147
Number of pages12
JournalClinical Immunology
Volume155
Issue number1
DOIs
Publication statusPublished - Nov-2014

Keywords

  • Hygiene hypothesis
  • Newborn infant
  • Cord blood
  • Gene expression
  • Innate immunity
  • Immune adaptation
  • REGULATORY T-CELLS
  • RUSSIAN KARELIA
  • INNATE IMMUNITY
  • MULTIPLE-SCLEROSIS
  • DENDRITIC CELLS
  • EXPRESSION
  • RECEPTOR
  • RESPONSES
  • FINLAND
  • CD46

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