Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria

P. Valent; C. Akin; L. Escribano; M. Foedinger; K. Hartmann; K. Brockow; M. Castells; W. R. Sperr; H. C. Kluin-Nelemans; N. A. T. Hamdy; O. Lortholary; J. Robyn; J. van Doormaal; K. Sotlar; A. W. Hauswirth; M. Arock; O. Hermine; A. Hellmann; M. Triggiani; M. Niedoszytko; L. B. Schwartz; A. Orfao; H.-P. Horny; D. D. Metcalfe

doi:10.1111/j.1365-2362.2007.01807.x

Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria

P. Valent^*, C. Akin, L. Escribano, M. Foedinger, K. Hartmann, K. Brockow, M. Castells, W. R. Sperr, H. C. Kluin-Nelemans, N. A. T. Hamdy, O. Lortholary, J. Robyn, J. van Doormaal, K. Sotlar, A. W. Hauswirth, M. Arock, O. Hermine, A. Hellmann, M. Triggiani, M. NiedoszytkoL. B. Schwartz, A. Orfao, H.-P. Horny, D. D. Metcalfe

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

688 Citations (Scopus)

Abstract

Although a classification for mastocytosis and diagnostic criteria are available, there remains a need to define standards for the application of diagnostic tests, clinical evaluations, and treatment responses. To address these demands, leading experts discussed current issues and standards in mastocytosis in a Working Conference. The present article provides the resulting outcome with consensus statements, which focus on the appropriate application of clinical and laboratory tests, patient selection for interventional therapy, and the selection of appropriate drugs. In addition, treatment response criteria for the various clinical conditions, disease-specific symptoms, and specific pathologies are provided. Resulting recommendations and algorithms should greatly facilitate the management of patients with mastocytosis in clinical practice, selection of patients for therapies, and the conduct of clinical trials.

Original language	English
Pages (from-to)	435-453
Number of pages	19
Journal	European Journal of Clinical Investigation
Volume	37
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2362.2007.01807.x
Publication status	Published - Jun-2007
Event	Standardization Conference 2005 - , Austria Duration: 3-Nov-2005 → 6-Nov-2005

Keywords

criteria
mastocytosis
patient selection
standardization
targeted drugs
MAST-CELL DISEASE
C-KIT MUTATION
ACUTE MYELOID-LEUKEMIA
GASTROINTESTINAL STROMAL TUMORS
AGGRESSIVE SYSTEMIC MASTOCYTOSIS
ORAL DISODIUM-CROMOGLYCATE
URINARY N-METHYLHISTAMINE
BONE-MARROW MASTOCYTOSIS
BLOOD MONONUCLEAR-CELLS
OF-THE-LITERATURE

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Valent, P., Akin, C., Escribano, L., Foedinger, M., Hartmann, K., Brockow, K., Castells, M., Sperr, W. R., Kluin-Nelemans, H. C., Hamdy, N. A. T., Lortholary, O., Robyn, J., van Doormaal, J., Sotlar, K., Hauswirth, A. W., Arock, M., Hermine, O., Hellmann, A., Triggiani, M., ... Metcalfe, D. D. (2007). Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria. European Journal of Clinical Investigation, 37(6), 435-453. https://doi.org/10.1111/j.1365-2362.2007.01807.x

@article{503d58ced73243dfa031e8dc0825f8af,

title = "Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria",

abstract = "Although a classification for mastocytosis and diagnostic criteria are available, there remains a need to define standards for the application of diagnostic tests, clinical evaluations, and treatment responses. To address these demands, leading experts discussed current issues and standards in mastocytosis in a Working Conference. The present article provides the resulting outcome with consensus statements, which focus on the appropriate application of clinical and laboratory tests, patient selection for interventional therapy, and the selection of appropriate drugs. In addition, treatment response criteria for the various clinical conditions, disease-specific symptoms, and specific pathologies are provided. Resulting recommendations and algorithms should greatly facilitate the management of patients with mastocytosis in clinical practice, selection of patients for therapies, and the conduct of clinical trials.",

keywords = "criteria, mastocytosis, patient selection, standardization, targeted drugs, MAST-CELL DISEASE, C-KIT MUTATION, ACUTE MYELOID-LEUKEMIA, GASTROINTESTINAL STROMAL TUMORS, AGGRESSIVE SYSTEMIC MASTOCYTOSIS, ORAL DISODIUM-CROMOGLYCATE, URINARY N-METHYLHISTAMINE, BONE-MARROW MASTOCYTOSIS, BLOOD MONONUCLEAR-CELLS, OF-THE-LITERATURE",

author = "P. Valent and C. Akin and L. Escribano and M. Foedinger and K. Hartmann and K. Brockow and M. Castells and Sperr, {W. R.} and Kluin-Nelemans, {H. C.} and Hamdy, {N. A. T.} and O. Lortholary and J. Robyn and {van Doormaal}, J. and K. Sotlar and Hauswirth, {A. W.} and M. Arock and O. Hermine and A. Hellmann and M. Triggiani and M. Niedoszytko and Schwartz, {L. B.} and A. Orfao and H.-P. Horny and Metcalfe, {D. D.}",

note = "Proceedings Paper 5; Standardization Conference 2005 ; Conference date: 03-11-2005 Through 06-11-2005",

year = "2007",

month = jun,

doi = "10.1111/j.1365-2362.2007.01807.x",

language = "English",

volume = "37",

pages = "435--453",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

publisher = "Wiley",

number = "6",

}

Valent, P, Akin, C, Escribano, L, Foedinger, M, Hartmann, K, Brockow, K, Castells, M, Sperr, WR, Kluin-Nelemans, HC, Hamdy, NAT, Lortholary, O, Robyn, J, van Doormaal, J, Sotlar, K, Hauswirth, AW, Arock, M, Hermine, O, Hellmann, A, Triggiani, M, Niedoszytko, M, Schwartz, LB, Orfao, A, Horny, H-P & Metcalfe, DD 2007, 'Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria', European Journal of Clinical Investigation, vol. 37, no. 6, pp. 435-453. https://doi.org/10.1111/j.1365-2362.2007.01807.x

TY - JOUR

T1 - Standards and standardization in mastocytosis

T2 - Standardization Conference 2005

AU - Valent, P.

AU - Akin, C.

AU - Escribano, L.

AU - Foedinger, M.

AU - Hartmann, K.

AU - Brockow, K.

AU - Castells, M.

AU - Sperr, W. R.

AU - Kluin-Nelemans, H. C.

AU - Hamdy, N. A. T.

AU - Lortholary, O.

AU - Robyn, J.

AU - van Doormaal, J.

AU - Sotlar, K.

AU - Hauswirth, A. W.

AU - Arock, M.

AU - Hermine, O.

AU - Hellmann, A.

AU - Triggiani, M.

AU - Niedoszytko, M.

AU - Schwartz, L. B.

AU - Orfao, A.

AU - Horny, H.-P.

AU - Metcalfe, D. D.

N1 - Proceedings Paper 5

PY - 2007/6

Y1 - 2007/6

N2 - Although a classification for mastocytosis and diagnostic criteria are available, there remains a need to define standards for the application of diagnostic tests, clinical evaluations, and treatment responses. To address these demands, leading experts discussed current issues and standards in mastocytosis in a Working Conference. The present article provides the resulting outcome with consensus statements, which focus on the appropriate application of clinical and laboratory tests, patient selection for interventional therapy, and the selection of appropriate drugs. In addition, treatment response criteria for the various clinical conditions, disease-specific symptoms, and specific pathologies are provided. Resulting recommendations and algorithms should greatly facilitate the management of patients with mastocytosis in clinical practice, selection of patients for therapies, and the conduct of clinical trials.

AB - Although a classification for mastocytosis and diagnostic criteria are available, there remains a need to define standards for the application of diagnostic tests, clinical evaluations, and treatment responses. To address these demands, leading experts discussed current issues and standards in mastocytosis in a Working Conference. The present article provides the resulting outcome with consensus statements, which focus on the appropriate application of clinical and laboratory tests, patient selection for interventional therapy, and the selection of appropriate drugs. In addition, treatment response criteria for the various clinical conditions, disease-specific symptoms, and specific pathologies are provided. Resulting recommendations and algorithms should greatly facilitate the management of patients with mastocytosis in clinical practice, selection of patients for therapies, and the conduct of clinical trials.

KW - criteria

KW - mastocytosis

KW - patient selection

KW - standardization

KW - targeted drugs

KW - MAST-CELL DISEASE

KW - C-KIT MUTATION

KW - ACUTE MYELOID-LEUKEMIA

KW - GASTROINTESTINAL STROMAL TUMORS

KW - AGGRESSIVE SYSTEMIC MASTOCYTOSIS

KW - ORAL DISODIUM-CROMOGLYCATE

KW - URINARY N-METHYLHISTAMINE

KW - BONE-MARROW MASTOCYTOSIS

KW - BLOOD MONONUCLEAR-CELLS

KW - OF-THE-LITERATURE

U2 - 10.1111/j.1365-2362.2007.01807.x

DO - 10.1111/j.1365-2362.2007.01807.x

M3 - Article

SN - 0014-2972

VL - 37

SP - 435

EP - 453

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 6

Y2 - 3 November 2005 through 6 November 2005

ER -

Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria

Abstract

Keywords

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