Statin Use and Cognitive Function: Population-Based Observational Study with Long-Term Follow-Up

Hanneke Joosten*, Sipke T. Visser, Marlise E. van Eersel, Ron T. Gansevoort, Henk J. G. Bilo, Joris P. Slaets, Gerbrand J. Izaks

*Corresponding author for this work

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Abstract

We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0-10; high performance, 11-12 points) in an observational study that included 4,095 community-dwelling participants aged 35-82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples matched on cardiovascular risk (N=1232) or propensity score for statin use (N=3609). We found that a total of 904 participants (10%) used a statin. Statin users were older than non-users: mean age (SD) 61 (10) vs. 52 (11) years (p

Original languageEnglish
Article numbere115755
Number of pages15
JournalPLoS ONE
Volume9
Issue number12
DOIs
Publication statusPublished - 26-Dec-2014

Keywords

  • CARDIOVASCULAR RISK PROFILE
  • OLDER-ADULTS
  • LATE-LIFE
  • DEMENTIA
  • DISEASE
  • IMPAIRMENT
  • CHOLESTEROL
  • PREVENTION

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