STN-DBS electrode placement accuracy and motor improvement in Parkinson's disease: systematic review and individual patient meta-analysis

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Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective neurosurgical treatment for Parkinson's disease. Surgical accuracy is a critical determinant to achieve an adequate DBS effect on motor performance. A two-millimetre surgical accuracy is commonly accepted, but scientific evidence is lacking. A systematic review and meta-analysis of study-level and individual patient data (IPD) was performed by a comprehensive search in MEDLINE, EMBASE and Cochrane Library. Primary outcome measures were (1) radial error between the implanted electrode and target; (2) DBS motor improvement on the Unified Parkinson's Disease Rating Scale part III (motor examination). On a study level, meta-regression analysis was performed. Also, publication bias was assessed. For IPD meta-analysis, a linear mixed effects model was used. Forty studies (1391 patients) were included, reporting radial errors of 0.45-1.86 mm. Errors within this range did not significantly influence the DBS effect on motor improvement. Additional IPD analysis (206 patients) revealed that a mean radial error of 1.13±0.75 mm did not significantly change the extent of DBS motor improvement. Our meta-analysis showed a huge publication bias on accuracy data in DBS. Therefore, the current literature does not provide an unequivocal upper threshold for acceptable accuracy of STN-DBS surgery. Based on the current literature, DBS-electrodes placed within a 2 mm range of the intended target do not have to be repositioned to enhance motor improvement after STN-DBS for Parkinson's disease. However, an indisputable upper cut-off value for surgical accuracy remains to be established. PROSPERO registration number is CRD42018089539.

Original languageEnglish
Number of pages9
JournalJournal of Neurology, Neurosurgery, and Psychiatry
Early online date7-Oct-2022
DOIs
Publication statusPublished - 2023

Keywords

  • META-ANALYSIS
  • PARKINSON'S DISEASE
  • ELECTRICAL STIMULATION
  • DEEP-BRAIN-STIMULATION
  • SUBTHALAMIC NUCLEUS STIMULATION
  • HARDWARE COMPLICATIONS
  • CLINICAL-OUTCOMES
  • INTRAOPERATIVE MRI
  • LEAD PLACEMENT
  • IMPLANTATION
  • LOCALIZATION
  • GUIDANCE
  • SEQUENCE

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