Stress and adaptation: Toward ecologically relevant animal models

Jaap M. Koolhaas, Sietse F. de Boer, Bauke Buwalda

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

Abstract

Animal models have contributed considerably to the current understanding of mechanisms underlying the role of stress in health and disease. Despite the progress made already, much more can be made by more carefully exploiting animals' and humans' shared biology, using ecologically relevant models. This allows a fundamental analysis of factors modulating individual adaptive capacity and hence individual vulnerability to disease. This article highlights an emerging scientific approach that uses a framework of interpretation that is more biologically oriented than previous approaches, to evaluate both the adaptive and maladaptive nature of the stress response in relation to existing environmental demands.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalCurrent Directions in Psychological Science
Volume15
Issue number3
DOIs
Publication statusPublished - Jun-2006

Keywords

  • stress
  • adaptation
  • animal models
  • biology
  • behavior
  • ALLOSTATIC LOAD
  • DISEASE
  • HEALTH
  • BRAIN

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