Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease

JCH van Oostrom, RP Maguire, CC Verschuuren-Bemelmans, LV van der Duin, J Pruim, RAC Roos, KL Leenders*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

Abstract

Among 27 preclinical carriers of the Huntington disease mutation (PMC), the authors found normal striatal values for MRI volumetry in 88% and for fluorodesoxyglucose PET metabolic index in 67%. Raclopride PET binding potential (RAC-BP) was decreased in 50% and correlated with increases in the product of age and CAG repeat length (p <0.0005). Dopamine D2 receptor availability measured by RAC-BP seems the most sensitive indicator of early neuronal impairment in PMC.

Original languageEnglish
Pages (from-to)941-943
Number of pages3
JournalNeurology
Volume65
Issue number6
Publication statusPublished - 27-Sep-2005

Keywords

  • DYSFUNCTION
  • ONSET

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