Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

Felix Poppelaars*, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen, Marc A. J. Seelen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular disease. In addition, hemodialysis alters MBL concentration and functional activity. The present study determines the predictive value of MBL levels for future cardiac events (C-event), cardiovascular events (CV-event) and all-cause mortality in HD patients.

Methods: We conducted a prospective study of 107 patients on maintenance hemodialysis. Plasma MBL, properdin, C3d and sC5b-9 was measured before and after one dialysis session. The association with future C-events, CV-events, and all-cause mortality was evaluated using Cox regression models.

Results: During median follow-up of 27 months, 36 participants developed 21 C-events and 36 CV-events, whereas 37 patients died. The incidence of C-events and CV-events was significantly higher in patients with low MBL levels (

Conclusions: Low MBL levels are associated with a higher risk for future C-events and CV-events. Therefore, MBL levels may help to identify hemodialysis patients who are at risk to develop cardiovascular disease.

Original languageEnglish
Article number236
Number of pages12
JournalJournal of translational medicine
Volume14
DOIs
Publication statusPublished - 5-Aug-2016

Keywords

  • Complement
  • MBL
  • Cardiovascular
  • Risk
  • Hemodialysis
  • ALL-CAUSE MORTALITY
  • MAINTENANCE HEMODIALYSIS
  • KIDNEY-TRANSPLANTATION
  • COMPLEMENT PATHWAY
  • GRAFT-SURVIVAL
  • DISEASE
  • DEFICIENCY
  • ATHEROSCLEROSIS
  • ASSOCIATION
  • DIALYSIS

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