Structural and functional characterisation of a lytic transglycosylase and two ω-transaminases

Eswarreddy Reddem

Structural and functional characterisation of a lytic transglycosylase and two ω-transaminases

Eswarreddy Reddem

Synthetic Organic Chemistry

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

This thesis describes the determination and analysis of 3D-structures of enzymes from two different enzyme classes, the lytic transglycosylase MltF from Pseudomonas aeruginosa and two ω-transaminases, an (R)-selective transaminase from an Arthrobacter species and an (S)-selective transaminase from a Pseudomonas species. Lytic transglycosylases may present new targets for the development of broad-spectrum antibiotics, while the transaminases are of biotechnological importance.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Dijkstra, Bauke W., Supervisor, External person Thunnissen, Andy, Co-supervisor
Award date	22-Dec-2015
Place of Publication	[Groningen]
Publisher	University of Groningen
Print ISBNs	978-90-367-8503-7
Electronic ISBNs	978-90-367-8502-0
Publication status	Published - 2015

Access to Document

Title and contentsFinal publisher's version, 90.6 KB
Chapter 1Final publisher's version, 13.7 MB
Chapter 2Final publisher's version, 4.59 MB
Chapter 3Final publisher's version, 14.4 MB
Chapter 4Final publisher's version, 15.4 MB
Chapter 5Final publisher's version, 23.6 MB
Chapter 6Final publisher's version, 1.5 MB
Complete thesisFinal publisher's version, 66 MB
PropositionsFinal publisher's version, 49.3 KB

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Cite this

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AB - This thesis describes the determination and analysis of 3D-structures of enzymes from two different enzyme classes, the lytic transglycosylase MltF from Pseudomonas aeruginosa and two ω-transaminases, an (R)-selective transaminase from an Arthrobacter species and an (S)-selective transaminase from a Pseudomonas species. Lytic transglycosylases may present new targets for the development of broad-spectrum antibiotics, while the transaminases are of biotechnological importance.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-8503-7

PB - University of Groningen

CY - [Groningen]

ER -