Structure and function of cerebral and mesenteric resistance arteries in low-dose endotoxin-infused pregnant rats

Marjon J Wiegman; Anne Marijn Van der Graaf; Robert H. Henning; Gerda G. Zeeman; Hendrik Buikema; Marijke M. Faas

doi:10.1016/j.preghy.2012.11.002

Structure and function of cerebral and mesenteric resistance arteries in low-dose endotoxin-infused pregnant rats

Marjon J Wiegman, Anne Marijn Van der Graaf, Robert H. Henning, Gerda G. Zeeman, Hendrik Buikema, Marijke M. Faas

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: Since the cerebrovasculature likely plays a prominent role in the pathophysiology of eclampsia, we assessed the effects of low-dose endotoxin-induced experimental preeclampsia on the function and structure of rat posterior cerebral arteries (PCA) and mesenteric arteries (MA).

Methods: Nonpregnant (NP) and pregnant (P) rats were infused with saline (NP-CTL, n = 9; P-CTL, n = 9) or low-dose endotoxin (NP-endotoxin, n = 9; P-endotoxin, n = 10). Myogenic activity, pressure of forced dilatation (FD) and structural properties were evaluated in PCA and MA.

Results: PCA underwent FD between 125 and 150 mmHg in P-endotoxin (repeated measures ANOVA vs 75 mmHg; P <0.05) and between 150 and 175 mmHg in P-CTL and NP animals (repeated measures ANOVA vs 75 mmHg; P <0.05). PCA myogenic tone was unaffected by pregnancy or endotoxin, however, pregnancy decreased the MA myogenic tone (P <0.05 vs NP). Passive characteristics of PCA and MA were unaffected by pregnancy or endotoxin.

Conclusion: Low-dose endotoxin-infusion during pregnancy, but not pregnancy alone, decreased the pressure of FD in PCA. This may predispose to cerebral autoregulatory breakthrough and edema formation during increased blood pressure as seen in eclampsia. (C) 2012 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	48-56
Number of pages	9
Journal	Pregnancy Hypertension
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.preghy.2012.11.002
Publication status	Published - Jan-2013

Keywords

Cerebral arteries
Mesenteric arteries
Low-dose endotoxin
Pregnancy
Myogenic tone

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@article{39bb62c536c8442990a9c5caba100b41,

title = "Structure and function of cerebral and mesenteric resistance arteries in low-dose endotoxin-infused pregnant rats",

abstract = "Objective: Since the cerebrovasculature likely plays a prominent role in the pathophysiology of eclampsia, we assessed the effects of low-dose endotoxin-induced experimental preeclampsia on the function and structure of rat posterior cerebral arteries (PCA) and mesenteric arteries (MA).Methods: Nonpregnant (NP) and pregnant (P) rats were infused with saline (NP-CTL, n = 9; P-CTL, n = 9) or low-dose endotoxin (NP-endotoxin, n = 9; P-endotoxin, n = 10). Myogenic activity, pressure of forced dilatation (FD) and structural properties were evaluated in PCA and MA.Results: PCA underwent FD between 125 and 150 mmHg in P-endotoxin (repeated measures ANOVA vs 75 mmHg; P <0.05) and between 150 and 175 mmHg in P-CTL and NP animals (repeated measures ANOVA vs 75 mmHg; P <0.05). PCA myogenic tone was unaffected by pregnancy or endotoxin, however, pregnancy decreased the MA myogenic tone (P <0.05 vs NP). Passive characteristics of PCA and MA were unaffected by pregnancy or endotoxin.Conclusion: Low-dose endotoxin-infusion during pregnancy, but not pregnancy alone, decreased the pressure of FD in PCA. This may predispose to cerebral autoregulatory breakthrough and edema formation during increased blood pressure as seen in eclampsia. (C) 2012 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.",

keywords = "Cerebral arteries, Mesenteric arteries, Low-dose endotoxin, Pregnancy, Myogenic tone",

author = "Wiegman, {Marjon J} and {Van der Graaf}, {Anne Marijn} and Henning, {Robert H.} and Zeeman, {Gerda G.} and Hendrik Buikema and Faas, {Marijke M.}",

year = "2013",

month = jan,

doi = "10.1016/j.preghy.2012.11.002",

language = "English",

volume = "3",

pages = "48--56",

journal = "Pregnancy Hypertension",

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T1 - Structure and function of cerebral and mesenteric resistance arteries in low-dose endotoxin-infused pregnant rats

AU - Wiegman, Marjon J

AU - Van der Graaf, Anne Marijn

AU - Henning, Robert H.

AU - Zeeman, Gerda G.

AU - Buikema, Hendrik

AU - Faas, Marijke M.

PY - 2013/1

Y1 - 2013/1

N2 - Objective: Since the cerebrovasculature likely plays a prominent role in the pathophysiology of eclampsia, we assessed the effects of low-dose endotoxin-induced experimental preeclampsia on the function and structure of rat posterior cerebral arteries (PCA) and mesenteric arteries (MA).Methods: Nonpregnant (NP) and pregnant (P) rats were infused with saline (NP-CTL, n = 9; P-CTL, n = 9) or low-dose endotoxin (NP-endotoxin, n = 9; P-endotoxin, n = 10). Myogenic activity, pressure of forced dilatation (FD) and structural properties were evaluated in PCA and MA.Results: PCA underwent FD between 125 and 150 mmHg in P-endotoxin (repeated measures ANOVA vs 75 mmHg; P <0.05) and between 150 and 175 mmHg in P-CTL and NP animals (repeated measures ANOVA vs 75 mmHg; P <0.05). PCA myogenic tone was unaffected by pregnancy or endotoxin, however, pregnancy decreased the MA myogenic tone (P <0.05 vs NP). Passive characteristics of PCA and MA were unaffected by pregnancy or endotoxin.Conclusion: Low-dose endotoxin-infusion during pregnancy, but not pregnancy alone, decreased the pressure of FD in PCA. This may predispose to cerebral autoregulatory breakthrough and edema formation during increased blood pressure as seen in eclampsia. (C) 2012 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

AB - Objective: Since the cerebrovasculature likely plays a prominent role in the pathophysiology of eclampsia, we assessed the effects of low-dose endotoxin-induced experimental preeclampsia on the function and structure of rat posterior cerebral arteries (PCA) and mesenteric arteries (MA).Methods: Nonpregnant (NP) and pregnant (P) rats were infused with saline (NP-CTL, n = 9; P-CTL, n = 9) or low-dose endotoxin (NP-endotoxin, n = 9; P-endotoxin, n = 10). Myogenic activity, pressure of forced dilatation (FD) and structural properties were evaluated in PCA and MA.Results: PCA underwent FD between 125 and 150 mmHg in P-endotoxin (repeated measures ANOVA vs 75 mmHg; P <0.05) and between 150 and 175 mmHg in P-CTL and NP animals (repeated measures ANOVA vs 75 mmHg; P <0.05). PCA myogenic tone was unaffected by pregnancy or endotoxin, however, pregnancy decreased the MA myogenic tone (P <0.05 vs NP). Passive characteristics of PCA and MA were unaffected by pregnancy or endotoxin.Conclusion: Low-dose endotoxin-infusion during pregnancy, but not pregnancy alone, decreased the pressure of FD in PCA. This may predispose to cerebral autoregulatory breakthrough and edema formation during increased blood pressure as seen in eclampsia. (C) 2012 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

KW - Cerebral arteries

KW - Mesenteric arteries

KW - Low-dose endotoxin

KW - Pregnancy

KW - Myogenic tone

U2 - 10.1016/j.preghy.2012.11.002

DO - 10.1016/j.preghy.2012.11.002

M3 - Article

SN - 2210-7797

VL - 3

SP - 48

EP - 56

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

IS - 1

ER -

Structure and function of cerebral and mesenteric resistance arteries in low-dose endotoxin-infused pregnant rats

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