Structure and function of mitochondrial supercomplexes

Natalya V. Dudkina; Roman Kouril; Katrin Peters; Hans-Peter Braun; Egbert J. Boekema

doi:10.1016/j.bbabio.2009.12.013

Structure and function of mitochondrial supercomplexes

Natalya V. Dudkina
, Roman Kouril
, Katrin Peters
, Hans-Peter Braun
, Egbert J. Boekema^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I. Ill and IV and in a dimeric form of complex V. between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed. (C) 2009 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	664-670
Number of pages	7
Journal	Biochimica et Biophysica Acta-Bioenergetics
Volume	1797
Issue number	6-7
DOIs	https://doi.org/10.1016/j.bbabio.2009.12.013
Publication status	Published - 2010
Event	16th European Bioenergetics Conference - , Poland Duration: 17-Jul-2010 → 22-Jul-2010

Keywords

Oxidative phosphorylation
Mitochondria
Respirasome
ATP synthase
Electron microscopy
Supercomplex
RESPIRATORY-CHAIN SUPERCOMPLEXES
BOVINE HEART-MITOCHONDRIA
OXIDOREDUCTASE COMPLEX-I
DIMERIC ATP SYNTHASE
CYTOCHROME-C-OXIDASE
3-DIMENSIONAL STRUCTURE
MAMMALIAN MITOCHONDRIA
OXIDATIVE-PHOSPHORYLATION
PLANT-MITOCHONDRIA
INNER MEMBRANES

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@article{90f942a472e4419b9d73f29642228ac5,

title = "Structure and function of mitochondrial supercomplexes",

abstract = "The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I. Ill and IV and in a dimeric form of complex V. between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed. (C) 2009 Elsevier B.V. All rights reserved.",

keywords = "Oxidative phosphorylation, Mitochondria, Respirasome, ATP synthase, Electron microscopy, Supercomplex, RESPIRATORY-CHAIN SUPERCOMPLEXES, BOVINE HEART-MITOCHONDRIA, OXIDOREDUCTASE COMPLEX-I, DIMERIC ATP SYNTHASE, CYTOCHROME-C-OXIDASE, 3-DIMENSIONAL STRUCTURE, MAMMALIAN MITOCHONDRIA, OXIDATIVE-PHOSPHORYLATION, PLANT-MITOCHONDRIA, INNER MEMBRANES",

author = "Dudkina, \{Natalya V.\} and Roman Kouril and Katrin Peters and Hans-Peter Braun and Boekema, \{Egbert J.\}",

year = "2010",

doi = "10.1016/j.bbabio.2009.12.013",

language = "English",

volume = "1797",

pages = "664--670",

journal = "Biochimica et Biophysica Acta-Bioenergetics",

issn = "0005-2728",

number = "6-7",

note = "16th European Bioenergetics Conference ; Conference date: 17-07-2010 Through 22-07-2010",

}

TY - JOUR

T1 - Structure and function of mitochondrial supercomplexes

AU - Dudkina, Natalya V.

AU - Kouril, Roman

AU - Peters, Katrin

AU - Braun, Hans-Peter

AU - Boekema, Egbert J.

PY - 2010

Y1 - 2010

N2 - The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I. Ill and IV and in a dimeric form of complex V. between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed. (C) 2009 Elsevier B.V. All rights reserved.

AB - The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I. Ill and IV and in a dimeric form of complex V. between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed. (C) 2009 Elsevier B.V. All rights reserved.

KW - Oxidative phosphorylation

KW - Mitochondria

KW - Respirasome

KW - ATP synthase

KW - Electron microscopy

KW - Supercomplex

KW - RESPIRATORY-CHAIN SUPERCOMPLEXES

KW - BOVINE HEART-MITOCHONDRIA

KW - OXIDOREDUCTASE COMPLEX-I

KW - DIMERIC ATP SYNTHASE

KW - CYTOCHROME-C-OXIDASE

KW - 3-DIMENSIONAL STRUCTURE

KW - MAMMALIAN MITOCHONDRIA

KW - OXIDATIVE-PHOSPHORYLATION

KW - PLANT-MITOCHONDRIA

KW - INNER MEMBRANES

U2 - 10.1016/j.bbabio.2009.12.013

DO - 10.1016/j.bbabio.2009.12.013

M3 - Article

SN - 0005-2728

VL - 1797

SP - 664

EP - 670

JO - Biochimica et Biophysica Acta-Bioenergetics

JF - Biochimica et Biophysica Acta-Bioenergetics

IS - 6-7

T2 - 16th European Bioenergetics Conference

Y2 - 17 July 2010 through 22 July 2010

ER -

Structure and function of mitochondrial supercomplexes

Abstract

Keywords

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