Structure of the diastereoisomeric salt of (–)-4-o-chloro­phenyl-2-hy­droxy-2-oxo-1,3,2-dioxa­phosphorinane-5-spiro­cyclo­hexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol

S.  Garciagranda; P. T. Beurskens; J. M. M. Smits; A. M. G. Kok; H. Wynberg

doi:10.1107/S0108270188008893

Structure of the diastereoisomeric salt of (–)-4-o-chlorophenyl-2-hydroxy-2-oxo-1,3,2-dioxaphosphorinane-5-spirocyclohexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol

S. Garciagranda, P. T. Beurskens, J. M. M. Smits, A. M. G. Kok, H. Wynberg

Chemical Biology 2

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

3 Citations (Scopus)

Abstract

C24H33CINO5P , M r = 481.95, orthorhombic, P2~2121, a=8.026(2), b= 16.103 (6), c = 19.169 (5) A, V= 2478 (2) A 3, z = 4, O x = 1.29gem -3, CuKa radiation, 2= 1.54184A, g= 22.73 cm -~, F(000) = 1024, R = 0.037, wR = 0.037 for 3596 observed reflections and 391 variables. The structure was solved by automatic application of the vector-search orientation function and the DIRDIF structure expansion procedure. The structure contains phosphorinane anions and ephedrine cations which are linked in a three-dimensional network by N-H...O and O-H...O hydrogen bonds. The phosphorinane ring is in the chair conformation. The ephedrine is in the usual extended form. The structure of a diastereoisomer is reported by Kok, Wynberg, Garcia-Granda, Beurskens & Smit [Acta Cryst. (1988), C44, 2235-2237].

Original language	English
Pages (from-to)	2233-2235
Number of pages	3
Journal	Acta Crystallographica Section C: Crystal Structure Communications
Volume	44
DOIs	https://doi.org/10.1107/S0108270188008893
Publication status	Published - 15-Dec-1988

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Structure of the Diastereoisomeric Salt of (-)-4-o-Chlorophenyl-2-hydroxy-
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Garciagranda, S., Beurskens, P. T., Smits, J. M. M., Kok, A. M. G., & Wynberg, H. (1988). Structure of the diastereoisomeric salt of (–)-4-o-chlorophenyl-2-hydroxy-2-oxo-1,3,2-dioxaphosphorinane-5-spirocyclohexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol. Acta Crystallographica Section C: Crystal Structure Communications, 44, 2233-2235. https://doi.org/10.1107/S0108270188008893

@article{55b8489b760347ec8427d34492aaba99,

title = "Structure of the diastereoisomeric salt of (–)-4-o-chlorophenyl-2-hydroxy-2-oxo-1,3,2-dioxaphosphorinane-5-spirocyclohexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol",

abstract = "C24H33CINO5P , M r = 481.95, orthorhombic, P2~2121, a=8.026(2), b= 16.103 (6), c = 19.169 (5) A, V= 2478 (2) A 3, z = 4, O x = 1.29gem -3, CuKa radiation, 2= 1.54184A, g= 22.73 cm -~, F(000) = 1024, R = 0.037, wR = 0.037 for 3596 observed reflections and 391 variables. The structure was solved by automatic application of the vector-search orientation function and the DIRDIF structure expansion procedure. The structure contains phosphorinane anions and ephedrine cations which are linked in a three-dimensional network by N-H...O and O-H...O hydrogen bonds. The phosphorinane ring is in the chair conformation. The ephedrine is in the usual extended form. The structure of a diastereoisomer is reported by Kok, Wynberg, Garcia-Granda, Beurskens & Smit [Acta Cryst. (1988), C44, 2235-2237]. ",

author = "S. Garciagranda and Beurskens, {P. T.} and Smits, {J. M. M.} and Kok, {A. M. G.} and H. Wynberg",

year = "1988",

month = dec,

day = "15",

doi = "10.1107/S0108270188008893",

language = "English",

volume = "44",

pages = "2233--2235",

journal = "Acta Crystallographica Section C: Crystal Structure Communications",

issn = "0108-2701",

}

Garciagranda, S, Beurskens, PT, Smits, JMM, Kok, AMG & Wynberg, H 1988, 'Structure of the diastereoisomeric salt of (–)-4-o-chlorophenyl-2-hydroxy-2-oxo-1,3,2-dioxaphosphorinane-5-spirocyclohexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol', Acta Crystallographica Section C: Crystal Structure Communications, vol. 44, pp. 2233-2235. https://doi.org/10.1107/S0108270188008893

Structure of the diastereoisomeric salt of (–)-4-o-chlorophenyl-2-hydroxy-2-oxo-1,3,2-dioxaphosphorinane-5-spirocyclohexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol. / Garciagranda, S. ; Beurskens, P. T.; Smits, J. M. M. et al.
In: Acta Crystallographica Section C: Crystal Structure Communications, Vol. 44, 15.12.1988, p. 2233-2235.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

TY - JOUR

T1 - Structure of the diastereoisomeric salt of (–)-4-o-chlorophenyl-2-hydroxy-2-oxo-1,3,2-dioxaphosphorinane-5-spirocyclohexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol

AU - Garciagranda, S.

AU - Beurskens, P. T.

AU - Smits, J. M. M.

AU - Kok, A. M. G.

AU - Wynberg, H.

PY - 1988/12/15

Y1 - 1988/12/15

N2 - C24H33CINO5P , M r = 481.95, orthorhombic, P2~2121, a=8.026(2), b= 16.103 (6), c = 19.169 (5) A, V= 2478 (2) A 3, z = 4, O x = 1.29gem -3, CuKa radiation, 2= 1.54184A, g= 22.73 cm -~, F(000) = 1024, R = 0.037, wR = 0.037 for 3596 observed reflections and 391 variables. The structure was solved by automatic application of the vector-search orientation function and the DIRDIF structure expansion procedure. The structure contains phosphorinane anions and ephedrine cations which are linked in a three-dimensional network by N-H...O and O-H...O hydrogen bonds. The phosphorinane ring is in the chair conformation. The ephedrine is in the usual extended form. The structure of a diastereoisomer is reported by Kok, Wynberg, Garcia-Granda, Beurskens & Smit [Acta Cryst. (1988), C44, 2235-2237].

AB - C24H33CINO5P , M r = 481.95, orthorhombic, P2~2121, a=8.026(2), b= 16.103 (6), c = 19.169 (5) A, V= 2478 (2) A 3, z = 4, O x = 1.29gem -3, CuKa radiation, 2= 1.54184A, g= 22.73 cm -~, F(000) = 1024, R = 0.037, wR = 0.037 for 3596 observed reflections and 391 variables. The structure was solved by automatic application of the vector-search orientation function and the DIRDIF structure expansion procedure. The structure contains phosphorinane anions and ephedrine cations which are linked in a three-dimensional network by N-H...O and O-H...O hydrogen bonds. The phosphorinane ring is in the chair conformation. The ephedrine is in the usual extended form. The structure of a diastereoisomer is reported by Kok, Wynberg, Garcia-Granda, Beurskens & Smit [Acta Cryst. (1988), C44, 2235-2237].

U2 - 10.1107/S0108270188008893

DO - 10.1107/S0108270188008893

M3 - Comment/Letter to the editor

SN - 0108-2701

VL - 44

SP - 2233

EP - 2235

JO - Acta Crystallographica Section C: Crystal Structure Communications

JF - Acta Crystallographica Section C: Crystal Structure Communications

ER -

Garciagranda S, Beurskens PT, Smits JMM, Kok AMG, Wynberg H. Structure of the diastereoisomeric salt of (–)-4-o-chlorophenyl-2-hydroxy-2-oxo-1,3,2-dioxaphosphorinane-5-spirocyclohexane and (1R,2S)-(–)-α-[(1-methylamino)ethyl]benzyl alcohol. Acta Crystallographica Section C: Crystal Structure Communications. 1988 Dec 15;44:2233-2235. doi: 10.1107/S0108270188008893