Struktur eines spannungsregulierten Membrantransporters aus Spermien

Martin F. Peter; Valeria Kalienkova; Cristina Paulino

doi:10.1007/s12268-023-2062-0

Struktur eines spannungsregulierten Membrantransporters aus Spermien

Martin F. Peter, Valeria Kalienkova, Cristina Paulino^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The sperm-specific Na⁺/H⁺ exchanger SLC9C1 stands out by its unique tripartite domain composition. It is the first known secondary-active transporter which is directly activated by membrane voltage via a voltage-sensing domain (VSD). Our cryo-EM structures of sea urchin SLC9C1 reveal the domain arrangement and new structural coupling elements, allowing us to propose a mechanism for a voltage-activated alternative access mechanism.

Original language	German
Pages (from-to)	721-724
Number of pages	4
Journal	BIOspektrum
Volume	29
Issue number	7
DOIs	https://doi.org/10.1007/s12268-023-2062-0
Publication status	Published - Nov-2023

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Struktur eines spannungsregulierten Membrantransporters aus SpermienFinal publisher's version, 488 KBLicence: CC BY

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AB - The sperm-specific Na+/H+ exchanger SLC9C1 stands out by its unique tripartite domain composition. It is the first known secondary-active transporter which is directly activated by membrane voltage via a voltage-sensing domain (VSD). Our cryo-EM structures of sea urchin SLC9C1 reveal the domain arrangement and new structural coupling elements, allowing us to propose a mechanism for a voltage-activated alternative access mechanism.

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Struktur eines spannungsregulierten Membrantransporters aus Spermien

Abstract

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