Studies on tableting properties of lactose: Part III. The consolidation behaviour of sieve fractions of crystalline α-lactose monohydrate

A. H. de Boer *, H. Vromans, C. F. Lerk, G. K. Bolhuis, K. D. Kussendrager, H. Bosch

*Corresponding author for this work

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    Abstract

    The consolidation and compaction behaviour of sieve fractions of crystalline α-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength
    Original languageEnglish
    Pages (from-to)145-150
    Number of pages6
    JournalPharmaceutisch weekblad-Scientific edition
    Volume8
    Issue number2
    DOIs
    Publication statusPublished - 25-Apr-1986

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