Studies to optimize selection  for immunomodulatory cancer therapy with focus on immunoPET

Iris Christina Kok

doi:10.33612/diss.179989520

Studies to optimize selection for immunomodulatory cancer therapy with focus on immunoPET

Iris Christina Kok

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

This thesis focuses on imaging with PET and radiolabeled immune
checkpoint inhibitors to increase the knowledge about these
medicines, their whole body distribution, drug target expression, and
factors determining patient response.
We performed first-in-human studies to assess drug biodistribution, uptake at the drugs target, heterogeneity in target expression and relation to uptake and treatment response.
In this thesis, we demonstrate how ImmunoPET imaging can combine
the target specificity of an antibody with the advantages of PET-based
visualization and quantification. In two reviews and our own work, we
show how this technique is being used in small smart trials to support
drug development and patient selection.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	de Vries, Liesbeth, Supervisor Jalving, Hilde, Co-supervisor de Groot, Derk Jan, Co-supervisor
Award date	23-Sep-2021
Place of Publication	[Groningen]
Publisher	University of Groningen
Print ISBNs	978-94-6416-679-8
Electronic ISBNs	978-94-6416-761-0
DOIs	https://doi.org/10.33612/diss.179989520
Publication status	Published - 2021

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10.33612/diss.179989520

Title and contentsFinal publisher's version, 2.06 MB
Chapter 1Final publisher's version, 582 KB
Chapter 2Final publisher's version, 402 KB
Chapter 3Final publisher's version, 721 KB
Chapter 4Final publisher's version, 1.97 MB
Chapter 5Final publisher's version, 1.13 MB
Chapter 7Final publisher's version, 1.25 MB
Chapter 8Final publisher's version, 903 KB
Chapter 11Final publisher's version, 80.5 KB
PropositionsFinal publisher's version, 1.46 MB

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Cite this

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title = "Studies to optimize selection for immunomodulatory cancer therapy with focus on immunoPET",

abstract = "This thesis focuses on imaging with PET and radiolabeled immune checkpoint inhibitors to increase the knowledge about these medicines, their whole body distribution, drug target expression, and factors determining patient response.We performed first-in-human studies to assess drug biodistribution, uptake at the drugs target, heterogeneity in target expression and relation to uptake and treatment response. In this thesis, we demonstrate how ImmunoPET imaging can combine the target specificity of an antibody with the advantages of PET-based visualization and quantification. In two reviews and our own work, we show how this technique is being used in small smart trials to support drug development and patient selection.",

author = "Kok, {Iris Christina}",

year = "2021",

doi = "10.33612/diss.179989520",

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school = "University of Groningen",

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AB - This thesis focuses on imaging with PET and radiolabeled immune checkpoint inhibitors to increase the knowledge about these medicines, their whole body distribution, drug target expression, and factors determining patient response.We performed first-in-human studies to assess drug biodistribution, uptake at the drugs target, heterogeneity in target expression and relation to uptake and treatment response. In this thesis, we demonstrate how ImmunoPET imaging can combine the target specificity of an antibody with the advantages of PET-based visualization and quantification. In two reviews and our own work, we show how this technique is being used in small smart trials to support drug development and patient selection.

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DO - 10.33612/diss.179989520

M3 - Thesis fully internal (DIV)

SN - 978-94-6416-679-8

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CY - [Groningen]

ER -