TY - JOUR
T1 - Substantiating the Short Burst Duration in Cortical Myoclonus
AU - van der Veen, Sterre
AU - Maliepaard, Amber
AU - van der Stouwe, Madelein
AU - Dalenberg, Jelle
AU - Tuitert, Inge
AU - Elting, Jan Willem J.
AU - Tijssen, Marina A.J.
N1 - Publisher Copyright:
© 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
PY - 2024/9/24
Y1 - 2024/9/24
N2 - Background: Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown. Objective: This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM. Methods: We manually identified the burst duration of 8 patients with CM, confirmed by electromyography–electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-SGCE positive and negative). Results: The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy. Conclusion: The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.
AB - Background: Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown. Objective: This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM. Methods: We manually identified the burst duration of 8 patients with CM, confirmed by electromyography–electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-SGCE positive and negative). Results: The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy. Conclusion: The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.
KW - anatomical classification
KW - burst duration
KW - cortical myoclonus
KW - electromyography
KW - myoclonus
UR - http://www.scopus.com/inward/record.url?scp=85204585470&partnerID=8YFLogxK
U2 - 10.1002/mds.29990
DO - 10.1002/mds.29990
M3 - Article
AN - SCOPUS:85204585470
SN - 0885-3185
JO - Movement Disorders
JF - Movement Disorders
ER -