Substrate exploitation of multicomponent reactions toward diverse scaffolds and applications in medicinal chemistry

Jingyao Li

Research output: ThesisThesis fully internal (DIV)

238 Downloads (Pure)

Abstract

MCR chemistry is an emerging and promising tool for organic synthesis and medicinal chemistry. In this thesis, we enriched the probable scaffolds of MCR by exploring its isocyanide, aldehyde and acid substrates. Besides, post-cyclization of MCR products was performed as well, and generated an efficient methodology towards drug-like compounds. The discovery of IL-17A antagonists through MCRs was accomplished in the last chapter, indicating the broad applicability of MCRs in the drug development process.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Dömling, Alex, Supervisor
  • Holak, Tad A., Supervisor, External person
Award date12-Jan-2021
Place of Publication[Groningen]
Publisher
DOIs
Publication statusPublished - 2021

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