Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalTherapeutic Drug Monitoring
Issue number2
Publication statusPublished - Apr-2023


  • Child
  • Humans
  • Ganciclovir/therapeutic use
  • Antiviral Agents/therapeutic use
  • Cytomegalovirus Infections/drug therapy
  • Valganciclovir/therapeutic use
  • Drug Monitoring

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