Successful treatment of an acquired haemorrhagic diathesis due to factor X deficiency with chemotherapy

E de Jager, R Bieger*, A Castel, P.M. Kluin

*Corresponding author for this work

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    A 70-yr-old woman presented with a severe haemorrhagic diathesis due to an acquired factor X deficiency. A plasma infusion study showed that exogenous factor X was eliminated very effectively from the patient's circulation. A bone marrow biopsy was consistent with plasma cell dyscrasia. Neither an abdominal fat biopsy nor the bone marrow biopsy confirmed an amyloidosis, although clinically no other diagnosis seemed possible. Treatment with intermittent chemotherapy, consisting of vincristine, cytoxan and prednisone, yielded definite clinical and laboratory improvement.

    Original languageEnglish
    Pages (from-to)352-354
    Number of pages3
    JournalEuropean Journal of Haematology
    Issue number5
    Publication statusPublished - May-2001


    • acquired factor X deficiency
    • amyloidosis
    • plasma cell dyscrasia
    • chemotherapy

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