[18F]fluorothymidine uptake in the porcine pancreatic elastase-induced model of abdominal aortic aneurysm

Richa Gandhi, Joanna Koch-Paszkowski, Charalampos Tsoumpas, Marc A. Bailey*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Downloads (Pure)

Abstract

The porcine pancreatic elastase (PPE) model is a common preclinical model of abdominal aortic aneurysms (AAA). Some notable characteristics of this model include the low aortic rupture rate, non-progressive disease course, and infra-renal AAA formation. Enhanced [18F]fluorothymidine ([18F]FLT) uptake on positron emission tomography/computed tomography (PET/CT) has previ-ously been reported in the angiotensin II-induced murine model of AAA. Here, we report our preliminary findings of investigating [18F]FLT uptake in the PPE murine model of AAA. [18F]FLT uptake was found to be substantially increased in the abdominal areas recovering from the surgery, whilst it was not found to be significantly increased within the PPE-induced AAA, as confirmed using in vivo PET/CT and ex vivo whole-organ gamma counting (PPE, n = 7; controls, n = 3). This finding suggests that the [18F]FLT may not be an appropriate radiotracer for this specific AAA model, and further studies with larger sample sizes are warranted to elucidate the pathobiology contributing to the reduced uptake of [18F]FLT in this model.

Original languageEnglish
Article number130
Number of pages5
JournalJournal of Imaging
Volume7
Issue number8
DOIs
Publication statusPublished - 4-Aug-2021
Externally publishedYes

Keywords

  • Abdominal aorta
  • Aneurysm
  • Mice
  • Positron emission tomography
  • Radioactive tracer

Cite this