1H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast

Paul E. Sijens; Martin J. Van Den Bent; Peter J.C.M. Nowak; Pieter Van Dijk; Matthijs Oudkerk

doi:10.1002/mrm.1910370214

¹H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast

Paul E. Sijens^*
, Martin J. Van Den Bent
, Peter J.C.M. Nowak
, Pieter Van Dijk
, Matthijs Oudkerk

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

118 Citations (Scopus)

26 Downloads (Pure)

Abstract

¹H MR spectra obtained by chemical shift imaging (CSI) of contrast- enhancing brain tumors before and after the administration of Gd-contrast agent were quantitated and compared with the results in normal brain tissue included in the volume of interest. Twenty-seven combined magnetic resonance imaging and spectroscopy (MRI, MRS) examinations of brain tumor lesions included T₁-weighted MRI and CSI (TR/TE 1500/135 ms double-spin echo) repeated 5-10 min after the administration of Gd-contrast agent (0.1-0.2 mM). In ¹H MR spectra of contrast-enhancing tumor Gd-contrast induced a mean loss of 15% of the peak area of choline-containing compounds (Cho, P < 0.001) that was correlated with precontrast Cho linewidth (r = -0.72, P < 0.00001). This phenomenon limits the diagnostic use of brain tumor MRS examinations performed immediately after contrast-enhanced MRI.

Original language	English
Pages (from-to)	222-225
Number of pages	4
Journal	Magnetic Resonance in Medicine
Volume	37
Issue number	2
DOIs	https://doi.org/10.1002/mrm.1910370214
Publication status	Published - Feb-1997
Externally published	Yes

Keywords

brain tumors
Gd-contrast agent
magnetic resonance imaging
magnetic resonance spectroscopy

Access to Document

10.1002/mrm.1910370214

1H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrastFinal publisher's version, 417 KBLicence: Taverne

Handle.net

Persistent link

Cite this

@article{be28d2ea5a0a4338ac5892b0a1c65e70,

title = "1H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast",

abstract = "1H MR spectra obtained by chemical shift imaging (CSI) of contrast- enhancing brain tumors before and after the administration of Gd-contrast agent were quantitated and compared with the results in normal brain tissue included in the volume of interest. Twenty-seven combined magnetic resonance imaging and spectroscopy (MRI, MRS) examinations of brain tumor lesions included T1-weighted MRI and CSI (TR/TE 1500/135 ms double-spin echo) repeated 5-10 min after the administration of Gd-contrast agent (0.1-0.2 mM). In 1H MR spectra of contrast-enhancing tumor Gd-contrast induced a mean loss of 15\% of the peak area of choline-containing compounds (Cho, P < 0.001) that was correlated with precontrast Cho linewidth (r = -0.72, P < 0.00001). This phenomenon limits the diagnostic use of brain tumor MRS examinations performed immediately after contrast-enhanced MRI.",

keywords = "brain tumors, Gd-contrast agent, magnetic resonance imaging, magnetic resonance spectroscopy",

author = "Sijens, \{Paul E.\} and \{Van Den Bent\}, \{Martin J.\} and Nowak, \{Peter J.C.M.\} and \{Van Dijk\}, Pieter and Matthijs Oudkerk",

year = "1997",

month = feb,

doi = "10.1002/mrm.1910370214",

language = "English",

volume = "37",

pages = "222--225",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - 1H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast

AU - Sijens, Paul E.

AU - Van Den Bent, Martin J.

AU - Nowak, Peter J.C.M.

AU - Van Dijk, Pieter

AU - Oudkerk, Matthijs

PY - 1997/2

Y1 - 1997/2

N2 - 1H MR spectra obtained by chemical shift imaging (CSI) of contrast- enhancing brain tumors before and after the administration of Gd-contrast agent were quantitated and compared with the results in normal brain tissue included in the volume of interest. Twenty-seven combined magnetic resonance imaging and spectroscopy (MRI, MRS) examinations of brain tumor lesions included T1-weighted MRI and CSI (TR/TE 1500/135 ms double-spin echo) repeated 5-10 min after the administration of Gd-contrast agent (0.1-0.2 mM). In 1H MR spectra of contrast-enhancing tumor Gd-contrast induced a mean loss of 15% of the peak area of choline-containing compounds (Cho, P < 0.001) that was correlated with precontrast Cho linewidth (r = -0.72, P < 0.00001). This phenomenon limits the diagnostic use of brain tumor MRS examinations performed immediately after contrast-enhanced MRI.

AB - 1H MR spectra obtained by chemical shift imaging (CSI) of contrast- enhancing brain tumors before and after the administration of Gd-contrast agent were quantitated and compared with the results in normal brain tissue included in the volume of interest. Twenty-seven combined magnetic resonance imaging and spectroscopy (MRI, MRS) examinations of brain tumor lesions included T1-weighted MRI and CSI (TR/TE 1500/135 ms double-spin echo) repeated 5-10 min after the administration of Gd-contrast agent (0.1-0.2 mM). In 1H MR spectra of contrast-enhancing tumor Gd-contrast induced a mean loss of 15% of the peak area of choline-containing compounds (Cho, P < 0.001) that was correlated with precontrast Cho linewidth (r = -0.72, P < 0.00001). This phenomenon limits the diagnostic use of brain tumor MRS examinations performed immediately after contrast-enhanced MRI.

KW - brain tumors

KW - Gd-contrast agent

KW - magnetic resonance imaging

KW - magnetic resonance spectroscopy

UR - https://www.scopus.com/pages/publications/0030614543

U2 - 10.1002/mrm.1910370214

DO - 10.1002/mrm.1910370214

M3 - Article

C2 - 9001146

AN - SCOPUS:0030614543

SN - 0740-3194

VL - 37

SP - 222

EP - 225

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 2

ER -