Supramolecular organotin(IV) dithiocarboxylates as potential antimicrobial agents

[No Value] Zia-ur-Rehman, Niaz Muhammady, Afzal Shah, Saqib Ali*, Ian S. Butler, Auke Meetsma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

A series of tri-, chlorodi-, and diorganotin(IV) derivatives of 4-(2-methoxyphenyl) piperazine-1-carbodithioate (L) {R = n-C4H9 (1), C6H11 (2), CH3 (3) and C6H5 (4)}, (n-C4H9)(2)SnClL (5) and R2SnL2 {R = n-C4H9 (6), C2H5 (7), CH3 (8)} have been synthesized by refluxing organotin(IV) chlorides with the ligand-salt in the appropriate molar ratio. Elemental analysis, Raman, IR, multinuclear NMR (H-1, C-13 and Sn-119), mass spectroscopic, and single-crystal X-ray crystallographic studies were undertaken to elucidate the structures of the new compounds both in solution and in the solid state. The X-ray diffraction work reveals supramolecular structures for 4 and 6, with distorted trigonal-bipyramidal and distorted octahedral geometries around Sn, respectively. The ligand and several of the new compounds are good antimicrobial agents.

Original languageEnglish
Pages (from-to)3238-3253
Number of pages16
JournalJournal of coordination chemistry
Volume65
Issue number18
DOIs
Publication statusPublished - 2012

Keywords

  • Organotin(IV) dithiocarboxylate
  • Molecular spectroscopy
  • Single-crystal X-ray structures
  • Antifungal and antibacterial activity
  • BIOLOGICAL-ACTIVITIES
  • CRYSTAL-STRUCTURES
  • COMPLEXES
  • DERIVATIVES
  • PYRROLIDINEDITHIOCARBAMATE
  • DIETHYLDITHIOCARBAMATE
  • DITHIOCARBAMATE
  • CYTOTOXICITY
  • STATE
  • ACID

Cite this