Surface modification of PCL-TCP scaffolds in rabbit calvaria defects: Evaluation of scaffold degradation profile, biomechanical properties and bone healing patterns

Alvin Yeo, Wah Jie Wong, Swee-Hin Teoh*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    65 Citations (Scopus)

    Abstract

    Traditionally, polycaprolactone (PG.) based scaffolds tend to degrade at a slow rate. Pretreatment of polycaprolactone-20% tricalcium phosphate (PCL-TCP) scaffolds under alkaline conditions can be utilized to increase the degradation rate and improve mechanical properties. Three groups of PCL-TCP scaffolds with varying pretreatment exposures with sodium hydroxide (NaOH) were studied in a rabbit calvaria defect model and analyzed at 2, 4, 8, 12, and 24 weeks. (Group A: Untreated, Group B: 3 M NaOH/48 h and Group C: 3 M NaOH/96 h). Micro-CT analysis demonstrated that scaffolds with increased surface roughness (Groups B and C) showed a greater impact on the overall volume loss during the early healing period between 2 and 8 weeks as compared to the untreated group. In addition, greater bone formation was detected in NaOH treated scaffolds as compared to the untreated group throughout the experiment. Scaffolds with increased surface roughness generally reported higher push out test and compressive strength values from 4 to 8 weeks of early healing. Interestingly, the mechanical properties displayed a decline in values from 12 weeks onwards in the modified groups suggesting a favorable breakdown or weakening of PCL-TCP scaffolds tailored for replacement by new bone formation. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 1358 1367, 2010

    Original languageEnglish
    Pages (from-to)1358-1367
    Number of pages10
    JournalJournal of Biomedical Materials Research. Part A
    Volume93A
    Issue number4
    DOIs
    Publication statusPublished - 15-Jun-2010

    Keywords

    • polycaprolactone
    • scaffold
    • degradation
    • bone
    • surface modification
    • TRICALCIUM PHOSPHATE SCAFFOLDS
    • GUIDED TISSUE REGENERATION
    • CRITICAL-SIZED DEFECTS
    • PLATELET-RICH PLASMA
    • POLYCAPROLACTONE SCAFFOLDS
    • BOVINE BONE
    • IN-VITRO
    • OSTEOBLAST
    • IMPLANTS
    • COMBINATION

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