Surgery for unusual histopathologic variants of esophageal neoplasms: a report of 23 cases with emphasis on histopathologic characteristics

J M Klaase, J B F Hulscher, G J A Offerhaus, F J W ten Kate, H Obertop, J J B van Lanschot

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22 Citations (Scopus)

Abstract

BACKGROUND: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse.

METHODS: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000.

RESULTS: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature.

CONCLUSIONS: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalAnnals of Surgical Oncology
Volume10
Issue number3
DOIs
Publication statusPublished - Apr-2003

Keywords

  • Adult
  • Aged
  • Carcinoma, Adenosquamous/pathology
  • Carcinoma, Small Cell/pathology
  • Carcinoma, Squamous Cell/pathology
  • Databases, Factual
  • Esophageal Neoplasms/pathology
  • Female
  • Humans
  • Male
  • Melanoma/pathology
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Survival

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