Surgery for unusual histopathologic variants of esophageal neoplasms: a report of 23 cases with emphasis on histopathologic characteristics

J M Klaase, J B F Hulscher, G J A Offerhaus, F J W ten Kate, H Obertop, J J B van Lanschot

    Research output: Contribution to journalArticleAcademicpeer-review

    25 Citations (Scopus)

    Abstract

    BACKGROUND: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse.

    METHODS: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000.

    RESULTS: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature.

    CONCLUSIONS: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.

    Original languageEnglish
    Pages (from-to)261-267
    Number of pages7
    JournalAnnals of Surgical Oncology
    Volume10
    Issue number3
    DOIs
    Publication statusPublished - Apr-2003

    Keywords

    • Adult
    • Aged
    • Carcinoma, Adenosquamous/pathology
    • Carcinoma, Small Cell/pathology
    • Carcinoma, Squamous Cell/pathology
    • Databases, Factual
    • Esophageal Neoplasms/pathology
    • Female
    • Humans
    • Male
    • Melanoma/pathology
    • Middle Aged
    • Prognosis
    • Retrospective Studies
    • Survival

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