Abstract
BACKGROUND: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse.
METHODS: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000.
RESULTS: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature.
CONCLUSIONS: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.
Original language | English |
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Pages (from-to) | 261-267 |
Number of pages | 7 |
Journal | Annals of Surgical Oncology |
Volume | 10 |
Issue number | 3 |
DOIs | |
Publication status | Published - Apr-2003 |
Keywords
- Adult
- Aged
- Carcinoma, Adenosquamous/pathology
- Carcinoma, Small Cell/pathology
- Carcinoma, Squamous Cell/pathology
- Databases, Factual
- Esophageal Neoplasms/pathology
- Female
- Humans
- Male
- Melanoma/pathology
- Middle Aged
- Prognosis
- Retrospective Studies
- Survival