Abstract
BACKGROUND: We investigated whether pre-existent goiter and well-differentiated thyroid cancer (WDTC) are associated with survival in anaplastic thyroid carcinoma (ATC).
METHODS: We analyzed medical records from 94 ATC patients, drawn from the Netherlands Cancer Registry, diagnosed in 17 hospitals between 1989 and 2009.
RESULTS: The 29 patients (31%) with pre-existent goiter, including 8 with WDTC, were younger than those without (median, 69 vs 76 years; P = .02). One-year overall survival was 9% (95% confidence interval [CI], 3% to 14%) with no difference between pre-existent goiter or not (overall survival, 14%; 95% CI, 1% to 26% vs overall survival, 6%; 95% CI, 0% to 13%]). Higher age was associated with a worse survival (hazard rate, 1.03; 95% CI, 1.01 to 1.06]), whereas the hazard to die was lower after surgery and/or radiotherapy (hazard rate, .37; 95% CI, .21 to.67 and hazard rate,. 22; 95% CI, .12 to .41, respectively).
CONCLUSIONS: ATC patients with pre-existent goiter were younger, yet survival was not significantly different between those with or without pre-existent goiter or WDTC. (C) 2015 Elsevier Inc. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 1013-1019 |
| Number of pages | 7 |
| Journal | American Journal of Surgery |
| Volume | 209 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun-2015 |
Keywords
- Anaplastic thyroid carcinoma
- Goiter
- Survival
- PHASE-II TRIAL
- SINGLE-INSTITUTION
- TARGETED THERAPIES
- PROGNOSTIC-FACTORS
- CARCINOMA
- RADIOTHERAPY
- SURGERY
- MANAGEMENT
- FOSBRETABULIN
- CHEMOTHERAPY