Susceptibility of Clinical Mycobacterium tuberculosis Isolates to a Potentially Less Toxic Derivate of Linezolid, PNU-100480

J. W. C. Alffenaar; T. van der Laan; S. Simons; T. S. van der Werf; P. J. van de Kasteele; H. de Neeling; D. van Soolingen

doi:10.1128/AAC.01297-10

Susceptibility of Clinical Mycobacterium tuberculosis Isolates to a Potentially Less Toxic Derivate of Linezolid, PNU-100480

J. W. C. Alffenaar^*, T. van der Laan, S. Simons, T. S. van der Werf, P. J. van de Kasteele, H. de Neeling, D. van Soolingen

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Article › Academic › peer-review

58 Citations (Scopus)

Abstract

Susceptibility of clinical Mycobacterium tuberculosis isolates to PNU-100480 and linezolid was evaluated by the MGIT 960 system. The isolates had various susceptibilities to isoniazid (INH), rifampin, ethambutol, and streptomycin. The mean MIC for PNU-100480 was 3.2 times lower than that for linezolid. Therefore, PNU-100480 is a promising candidate to be developed further as an adjunct in the treatment of multidrug-and extensively drug-resistant tuberculosis (MDR/XDR-TB).

Original language	English
Pages (from-to)	1287-1289
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01297-10
Publication status	Published - Mar-2011

Keywords

MULTIDRUG-RESISTANT TUBERCULOSIS
MITOCHONDRIAL PROTEIN-SYNTHESIS
MURINE MODEL
OXAZOLIDINONES
PHARMACOKINETICS
TOLERABILITY
INHIBITION
EFFICACY
DRUGS

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10.1128/AAC.01297-10

Cite this

@article{e5b171472fda48ae8ee5bf8cfba35ff7,

title = "Susceptibility of Clinical Mycobacterium tuberculosis Isolates to a Potentially Less Toxic Derivate of Linezolid, PNU-100480",

abstract = "Susceptibility of clinical Mycobacterium tuberculosis isolates to PNU-100480 and linezolid was evaluated by the MGIT 960 system. The isolates had various susceptibilities to isoniazid (INH), rifampin, ethambutol, and streptomycin. The mean MIC for PNU-100480 was 3.2 times lower than that for linezolid. Therefore, PNU-100480 is a promising candidate to be developed further as an adjunct in the treatment of multidrug-and extensively drug-resistant tuberculosis (MDR/XDR-TB).",

keywords = "MULTIDRUG-RESISTANT TUBERCULOSIS, MITOCHONDRIAL PROTEIN-SYNTHESIS, MURINE MODEL, OXAZOLIDINONES, PHARMACOKINETICS, TOLERABILITY, INHIBITION, EFFICACY, DRUGS",

author = "Alffenaar, {J. W. C.} and {van der Laan}, T. and S. Simons and {van der Werf}, {T. S.} and {van de Kasteele}, {P. J.} and {de Neeling}, H. and {van Soolingen}, D.",

year = "2011",

month = mar,

doi = "10.1128/AAC.01297-10",

language = "English",

volume = "55",

pages = "1287--1289",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "1098-6596",

publisher = "AMER SOC MICROBIOLOGY",

number = "3",

}

Susceptibility of Clinical Mycobacterium tuberculosis Isolates to a Potentially Less Toxic Derivate of Linezolid, PNU-100480. / Alffenaar, J. W. C.; van der Laan, T.; Simons, S.; van der Werf, T. S.; van de Kasteele, P. J.; de Neeling, H.; van Soolingen, D.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 3, 03.2011, p. 1287-1289.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Susceptibility of Clinical Mycobacterium tuberculosis Isolates to a Potentially Less Toxic Derivate of Linezolid, PNU-100480

AU - Alffenaar, J. W. C.

AU - van der Laan, T.

AU - Simons, S.

AU - van der Werf, T. S.

AU - van de Kasteele, P. J.

AU - de Neeling, H.

AU - van Soolingen, D.

PY - 2011/3

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N2 - Susceptibility of clinical Mycobacterium tuberculosis isolates to PNU-100480 and linezolid was evaluated by the MGIT 960 system. The isolates had various susceptibilities to isoniazid (INH), rifampin, ethambutol, and streptomycin. The mean MIC for PNU-100480 was 3.2 times lower than that for linezolid. Therefore, PNU-100480 is a promising candidate to be developed further as an adjunct in the treatment of multidrug-and extensively drug-resistant tuberculosis (MDR/XDR-TB).

AB - Susceptibility of clinical Mycobacterium tuberculosis isolates to PNU-100480 and linezolid was evaluated by the MGIT 960 system. The isolates had various susceptibilities to isoniazid (INH), rifampin, ethambutol, and streptomycin. The mean MIC for PNU-100480 was 3.2 times lower than that for linezolid. Therefore, PNU-100480 is a promising candidate to be developed further as an adjunct in the treatment of multidrug-and extensively drug-resistant tuberculosis (MDR/XDR-TB).

KW - MULTIDRUG-RESISTANT TUBERCULOSIS

KW - MITOCHONDRIAL PROTEIN-SYNTHESIS

KW - MURINE MODEL

KW - OXAZOLIDINONES

KW - PHARMACOKINETICS

KW - TOLERABILITY

KW - INHIBITION

KW - EFFICACY

KW - DRUGS

U2 - 10.1128/AAC.01297-10

DO - 10.1128/AAC.01297-10

M3 - Article

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EP - 1289

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 1098-6596

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