Susceptibility Testing of Antibiotics That Degrade Faster than the Doubling Time of Slow-Growing Mycobacteria: Ertapenem Sterilizing Effect versus Mycobacterium tuberculosis

Shashikant Srivastava, Sander P. van Rijn, A. Mireille A. Wessels, Jan-Willem C. Alffenaar*, Tawanda Gumbo

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Drug susceptibility tests (DSTs) for Mycobacterium tuberculosis require at least 7 days of incubation. Drugs that are unstable at 37 degrees C, such as ertapenem, are likely to be degraded before killing or inhibiting slow-growing bacteria. This would alter the MICs of these drugs, including ertapenem, leading to falsely high MICs. Here, we describe a new strategy we developed to perform DSTs and measure MICs for such unstable compounds.

Original languageEnglish
Pages (from-to)3193-3195
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number5
DOIs
Publication statusPublished - May-2016

Keywords

  • CARBAPENEMS
  • MONOTHERAPY
  • CLAVULANATE
  • RESISTANT
  • MODEL

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