SYMPTOMATOLOGY AND GROWTH IN INFANTS WITH COWS MILK PROTEIN INTOLERANCE USING 2 DIFFERENT WHEY-PROTEIN HYDROLYSATE BASED FORMULAS IN A PRIMARY HEALTH-CARE SETTING

JJM VERWIMP, JG BINDELS, M BARENTS, HSA HEYMANS

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Both growth and the course of allergic symptoms were evaluated in 79 infants with cow's milk protein intolerance, aged three months or younger, diagnosed by standard elimination/provocation and treated with a whey-hydrolysate based infant formula: Nutrilon Pept(R) or Pepti Junior(R). The efficacy of both products, in terms of symptomatology and growth, was compared with each other. The products differ in fat source (Pepti Junior 50% of its fat as MCT, Nutrilon Pepti normal LCT fat blend) and the presence of lactose (Pepti Junior: lactose free; Nutrilon Pepti: 40% of its carbohydrate as lactose). The study was part of a large project that aimed at standardising the approach towards cow's milk protein intolerance in Baby Health Clinics. Nearly 50 Baby Health Clinics participated in this project.

In this study, growth and symptomatology (skin, respiratory tract, gastrointestinal tract) were monitored during an intervention period of at least 10 weeks. Infants in both feeding groups showed normal growth, and in at least 80% of the infants an improvement of the overall symptomatology could be seen during the intervention period. Most profound were the decreases in prevalence and severity of eczema and infantile colic. No differences in efficacy were found in this study between the two infant formulas. It was concluded that the exclusive use of either whey hydrolysate based infant formula resulted in an improvement of allergic symptoms and in normal growth in infants diagnosed by elimination/provocation for cow's milk protein intolerance in a Primary Health Care setting.

Original languageEnglish
Pages (from-to)S39-S48
Number of pages10
JournalEuropean Journal of Clinical Nutrition
Volume49
Publication statusPublished - Sep-1995
EventWorkshop on the Role of Hypoallergenic Formulae in Cows Milk Allergy and Allergy Prevention -
Duration: 1-Mar-1995 → …

Keywords

  • COWS MILK PROTEIN INTOLERANCE
  • WHEY-HYDROLYSATE BASED INFANT FORMULA
  • ALLERGIC SYMPTOMS
  • TREATMENT
  • GROWTH
  • 1ST 3 YEARS
  • ATOPIC-DERMATITIS
  • CHILDREN
  • ALLERGY
  • AVOIDANCE
  • TRIAL
  • LIFE

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