TY - JOUR
T1 - Synthesis and biological evaluation of gramicidin S dimers
AU - Grotenbreg, Gijsbert M.
AU - Witte, Martin D.
AU - Hooft, Peter A.V. van
AU - Spalburg, Emile
AU - Reiß, Philipp
AU - Noort, Daan
AU - Neeling, Albert J. de
AU - Koert, Ulrich
AU - Marel, Gijsbert A. van der
AU - Overkleeft, Herman S.
AU - Overhand, Mark
N1 - Relation: http://www.rug.nl/research/stratingh/
date_submitted:2013
Rights: University of Groningen, Stratingh Institute for Chemistry
PY - 2005
Y1 - 2005
N2 - The design and synthesis of analogues of the cyclic β-sheet peptide gramicidin S (GS), having additional functionalities in their turn regions, is reported. The monomeric GS analogues were transformed into dimers and their activities towards biological membranes, through antimicriobial and hemolytic assays, were evaluated. Finally, conductivity measurements have been performed to elucidate ion channel forming properties.
AB - The design and synthesis of analogues of the cyclic β-sheet peptide gramicidin S (GS), having additional functionalities in their turn regions, is reported. The monomeric GS analogues were transformed into dimers and their activities towards biological membranes, through antimicriobial and hemolytic assays, were evaluated. Finally, conductivity measurements have been performed to elucidate ion channel forming properties.
M3 - Article
VL - 3
SP - 233
EP - 238
JO - Organic & Biomolecular Chemistry
JF - Organic & Biomolecular Chemistry
IS - 2
ER -