Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands

Y Liao*, AP Kozikowski, A Guidotti, E Costa

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    26 Citations (Scopus)

    Abstract

    A series of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27. (C) 1998 Elsevier Science Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)2099 - 2102
    Number of pages4
    JournalBioorganic & Medicinal Chemistry Letters
    Volume8
    Issue number16
    DOIs
    Publication statusPublished - 18-Aug-1998

    Keywords

    • PRIMARY CULTURES
    • POTENT
    • SITES
    • CELLS

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