Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands

Y Liao; AP Kozikowski; A Guidotti; E Costa

doi:10.1016/s0960-894x(98)00374-6

Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands

Y Liao^*, AP Kozikowski, A Guidotti, E Costa

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

A series of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27. (C) 1998 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	2099 - 2102
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	8
Issue number	16
DOIs	https://doi.org/10.1016/s0960-894x(98)00374-6
Publication status	Published - 18-Aug-1998

Keywords

PRIMARY CULTURES
POTENT
SITES
CELLS

Access to Document

10.1016/s0960-894x(98)00374-6

Cite this

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title = "Synthesis and pharmacological evaluation of benzofuran-acetamides as {"}antineophobic{"} mitochondrial DBI receptor complex ligands",

abstract = "A series of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27. (C) 1998 Elsevier Science Ltd. All rights reserved.",

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author = "Y Liao and AP Kozikowski and A Guidotti and E Costa",

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AU - Liao, Y

AU - Kozikowski, AP

AU - Guidotti, A

AU - Costa, E

PY - 1998/8/18

Y1 - 1998/8/18

N2 - A series of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27. (C) 1998 Elsevier Science Ltd. All rights reserved.

AB - A series of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27. (C) 1998 Elsevier Science Ltd. All rights reserved.

KW - PRIMARY CULTURES

KW - POTENT

KW - SITES

KW - CELLS

U2 - 10.1016/s0960-894x(98)00374-6

DO - 10.1016/s0960-894x(98)00374-6

M3 - Article

VL - 8

SP - 2099

EP - 2102

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

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