Synthesis and photooxidation of furylthymines; chemiexcitation model studies

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Abstract

A method for the synthesis of 1-(5-methyl-2-furoyl)thymine (7) and 1-(5-methyl-2-furyl)thymine (8) is described. Trimethylsilyliodide catalysed addition of 5-methyl-2,4-bis(trimethylsilyloxy)pyrimidine (9) to 2-methyl-2,5-dihydro-2,5-dimethoxyfuran yielded the new thymine derivative 13. Photooxidations of 7 and 8 gave not the expected addition products but furan endoperoxides and hydroperoxides and the novel rearrangement product 1-(3-keto-1-butenyl)-thymine.
Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalRecueil des Travaux Chimiques des Pays-Bas
Volume103
Issue number6
DOIs
Publication statusPublished - 1984

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