Synthesis of [18F]fluoro-labeled progestins for PET

TJ DEGROOT; Aalt Verhagen; Philippus Elsinga; Willem Vaalburg

Synthesis of [18F]fluoro-labeled progestins for PET

TJ DEGROOT^*, Aalt Verhagen, Philippus Elsinga, Willem Vaalburg

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

The synthesis of 21-[F-18]fluoro-16-alpha-methyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-ethyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-methylprogesterone and 21-[F-18]fluoro-16-alpha-ethylprogesterone is described. These compounds are prepared with a specific activity greater than 200 TBq/mmol (5000 Ci/mmol) from the corresponding tosylates in 10% radiochemical yield (EOB). A remote controlled system has been developed for this synthesis.

Original language	English
Pages (from-to)	471-474
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	42
Issue number	5
Publication status	Published - 1991

Keywords

BREAST-CANCER
RECEPTORS
RADIOTRACER
ESTROGEN

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@article{124dd86f00a247b7bed836b4856d4239,

title = "Synthesis of [18F]fluoro-labeled progestins for PET",

abstract = "The synthesis of 21-[F-18]fluoro-16-alpha-methyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-ethyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-methylprogesterone and 21-[F-18]fluoro-16-alpha-ethylprogesterone is described. These compounds are prepared with a specific activity greater than 200 TBq/mmol (5000 Ci/mmol) from the corresponding tosylates in 10% radiochemical yield (EOB). A remote controlled system has been developed for this synthesis.",

keywords = "BREAST-CANCER, RECEPTORS, RADIOTRACER, ESTROGEN",

author = "TJ DEGROOT and Aalt Verhagen and Philippus Elsinga and Willem Vaalburg",

year = "1991",

language = "English",

volume = "42",

pages = "471--474",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

number = "5",

}

TY - JOUR

T1 - Synthesis of [18F]fluoro-labeled progestins for PET

AU - DEGROOT, TJ

AU - Verhagen, Aalt

AU - Elsinga, Philippus

AU - Vaalburg, Willem

PY - 1991

Y1 - 1991

N2 - The synthesis of 21-[F-18]fluoro-16-alpha-methyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-ethyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-methylprogesterone and 21-[F-18]fluoro-16-alpha-ethylprogesterone is described. These compounds are prepared with a specific activity greater than 200 TBq/mmol (5000 Ci/mmol) from the corresponding tosylates in 10% radiochemical yield (EOB). A remote controlled system has been developed for this synthesis.

AB - The synthesis of 21-[F-18]fluoro-16-alpha-methyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-ethyl-19-norprogesterone, 21-[F-18]fluoro-16-alpha-methylprogesterone and 21-[F-18]fluoro-16-alpha-ethylprogesterone is described. These compounds are prepared with a specific activity greater than 200 TBq/mmol (5000 Ci/mmol) from the corresponding tosylates in 10% radiochemical yield (EOB). A remote controlled system has been developed for this synthesis.

KW - BREAST-CANCER

KW - RECEPTORS

KW - RADIOTRACER

KW - ESTROGEN

M3 - Article

SN - 0969-8043

VL - 42

SP - 471

EP - 474

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 5

ER -

Synthesis of [18F]fluoro-labeled progestins for PET

Abstract

Keywords

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