SYNTHESIS OF 6-ALPHA-[F-18]FLUOROPROGESTERONE - A FIRST STEP TOWARDS A POTENTIAL RECEPTOR-LIGAND FOR PET

TJ DEGROOT; AH BRAKER; PH ELSINGA; GM VISSER; W VAALBURG

SYNTHESIS OF 6-ALPHA-[F-18]FLUOROPROGESTERONE - A FIRST STEP TOWARDS A POTENTIAL RECEPTOR-LIGAND FOR PET

TJ DEGROOT^*, AH BRAKER, PH ELSINGA, GM VISSER, W VAALBURG

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

7 Citations (Scopus)

Abstract

6 alpha-[F-18]Fluoroprogesterone 3 was prepared by the BF3.Et(2) O-catalyzed reaction of progest-5 alpha,6 alpha-epoxy-3,20-bisketal 1 and [F-18]fluoride as a possible route for the in vivo visualization of progesterone receptors by PET. The radiochemical yield of 3 was 25% (EOB) and the sp. act. was 5 MBq/mu mol (100 Ci/mol, EOS).

Original language	English
Pages (from-to)	811-813
Number of pages	3
Journal	Applied Radiation and Isotopes
Volume	45
Issue number	7
Publication status	Published - Jul-1994

Keywords

POSITRON EMISSION TOMOGRAPHY
PROGESTERONE-RECEPTOR
BREAST-CANCER
F-18
21-<F-18>FLUORO-16-ALPHA-ETHYL-19-NORPROGESTERONE
PROGESTINS
TUMORS

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@article{05142fdbd42144d79f35c043ccc8d49f,

title = "SYNTHESIS OF 6-ALPHA-[F-18]FLUOROPROGESTERONE - A FIRST STEP TOWARDS A POTENTIAL RECEPTOR-LIGAND FOR PET",

abstract = "6 alpha-[F-18]Fluoroprogesterone 3 was prepared by the BF3.Et(2) O-catalyzed reaction of progest-5 alpha,6 alpha-epoxy-3,20-bisketal 1 and [F-18]fluoride as a possible route for the in vivo visualization of progesterone receptors by PET. The radiochemical yield of 3 was 25% (EOB) and the sp. act. was 5 MBq/mu mol (100 Ci/mol, EOS).",

keywords = "POSITRON EMISSION TOMOGRAPHY, PROGESTERONE-RECEPTOR, BREAST-CANCER, F-18, 21-<F-18>FLUORO-16-ALPHA-ETHYL-19-NORPROGESTERONE, PROGESTINS, TUMORS",

author = "TJ DEGROOT and AH BRAKER and PH ELSINGA and GM VISSER and W VAALBURG",

year = "1994",

month = jul,

language = "English",

volume = "45",

pages = "811--813",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

number = "7",

}

TY - JOUR

T1 - SYNTHESIS OF 6-ALPHA-[F-18]FLUOROPROGESTERONE - A FIRST STEP TOWARDS A POTENTIAL RECEPTOR-LIGAND FOR PET

AU - DEGROOT, TJ

AU - BRAKER, AH

AU - ELSINGA, PH

AU - VISSER, GM

AU - VAALBURG, W

PY - 1994/7

Y1 - 1994/7

N2 - 6 alpha-[F-18]Fluoroprogesterone 3 was prepared by the BF3.Et(2) O-catalyzed reaction of progest-5 alpha,6 alpha-epoxy-3,20-bisketal 1 and [F-18]fluoride as a possible route for the in vivo visualization of progesterone receptors by PET. The radiochemical yield of 3 was 25% (EOB) and the sp. act. was 5 MBq/mu mol (100 Ci/mol, EOS).

AB - 6 alpha-[F-18]Fluoroprogesterone 3 was prepared by the BF3.Et(2) O-catalyzed reaction of progest-5 alpha,6 alpha-epoxy-3,20-bisketal 1 and [F-18]fluoride as a possible route for the in vivo visualization of progesterone receptors by PET. The radiochemical yield of 3 was 25% (EOB) and the sp. act. was 5 MBq/mu mol (100 Ci/mol, EOS).

KW - POSITRON EMISSION TOMOGRAPHY

KW - PROGESTERONE-RECEPTOR

KW - BREAST-CANCER

KW - F-18

KW - 21-<F-18>FLUORO-16-ALPHA-ETHYL-19-NORPROGESTERONE

KW - PROGESTINS

KW - TUMORS

M3 - Comment/Letter to the editor

SN - 0969-8043

VL - 45

SP - 811

EP - 813

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 7

ER -

SYNTHESIS OF 6-ALPHA-[F-18]FLUOROPROGESTERONE - A FIRST STEP TOWARDS A POTENTIAL RECEPTOR-LIGAND FOR PET

Abstract

Keywords

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