Abstract
3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.
| Original language | English |
|---|---|
| Pages (from-to) | 318-323 |
| Number of pages | 6 |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2007 |
Keywords
- AGROBACTERIUM-RADIOBACTER AD1
- HALOHYDRIN DEHALOGENASE
- CHEMOENZYMATIC SYNTHESIS
- AROMATIC EPOXIDES
- ENANTIOSELECTIVITY
- ENANTIOMERS
- SITE
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CCDC 605888: Experimental Crystal Structure Determination
Haak, R. (Contributor), Tarabiono, C. (Contributor), Janssen, D. B. (Contributor), Minnaard, A. (Contributor), De Vries, J. G. (Contributor) & Feringa, B. L. (Contributor), University of Groningen, 27-Apr-2006
DOI: 10.5517/ccnbgs6
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