Synthesis of Realistic Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging Data

Irene Polycarpou*, Georgios Soultanidis, Charalampos Tsoumpas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

The investigation of the performance of different positron emission tomography (PET) reconstruction and motion compensation methods requires accurate and realistic representation of the anatomy and motion trajectories as observed in real subjects during acquisitions. The generation of well-controlled clinical datasets is difficult due to the many different clinical protocols, scanner specifications, patient sizes, and physiological variations. Alternatively, computational phantoms can be used to generate large data sets for different disease states, providing a ground truth. Several studies use registration of dynamic images to derive voxel deformations to create moving computational phantoms. These phantoms together with simulation software generate raw data. This paper proposes a method for the synthesis of dynamic PET data using a fast analytic method. This is achieved by incorporating realistic models of respiratory motion into a numerical phantom to generate datasets with continuous and variable motion with magnetic resonance imaging (MRI)-derived motion modeling and high resolution MRI images. In this paper, data sets for two different clinical traces are presented, 18F-FDG and 68Ga-PSMA. This approach incorporates realistic models of respiratory motion to generate temporally and spatially correlated MRI and PET data sets, as those expected to be obtained from simultaneous PET-MRI acquisitions.

Original languageEnglish
Pages (from-to)703-711
Number of pages9
JournalIeee transactions on medical imaging
Volume37
Issue number3
DOIs
Publication statusPublished - Mar-2018
Externally publishedYes

Keywords

  • Computer simulation
  • molecular imaging
  • motion compensation
  • PET
  • phantoms

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