Synthetic Minimal Cell: Self-Reproduction of the Boundary Layer

Marten Exterkate, Arnold J M Driessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
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Abstract

A critical aspect in the bottom-up construction of a synthetic minimal cell is to develop an entity that is capable of self-reproduction. A key role in this process is the expansion and division of the boundary layer that surrounds the compartment, a process in which content loss has to be avoided and the barrier function maintained. Here, we describe the latest developments regarding self-reproduction of a boundary layer with a focus on the growth and division of phospholipid-based membranes in the context of a synthetic minimal cell.

Original languageEnglish
Article number02955
Pages (from-to)5293-5303
Number of pages11
JournalACS Omega
Volume4
Issue number3
DOIs
Publication statusPublished - 31-Mar-2019

Keywords

  • synthetic biology
  • minimal cell
  • SELF-REPRODUCTION
  • MEMBRANE PHOSPHOLIPID-SYNTHESIS
  • IN-VITRO RECONSTITUTION
  • FATTY-ACID SYNTHASES
  • ESCHERICHIA-COLI
  • FLIP-FLOP
  • PROTEIN TRANSLOCATION
  • BACTERIAL LIPIDS
  • DIVISION
  • VESICLES
  • MODEL

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