Systematic review of cost-of-illness studies in hand eczema

Klaziena Politiek, Jart A. F. Oosterhaven, Karin M. Vermeulen, Marie-Louise A. Schuttelaar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)


The individual burden of disease in hand eczema patients is considerable. However, little is known about the socio-economic impact of this disease. The aims of this review were to evaluate the literature on cost-of-illness in hand eczema, and to compose a checklist for future use. The literature was retrieved from the MEDLINE and EMBASE databases up to October 2015. Quality evaluation was based on seven relevant items in cost-of-illness studies. Cost data ( direct and indirect) were extracted and converted into euros ( 2014 price level) by use of the Dutch Consumer Price Index. Six articles were included. The mean annual total cost per patient ranged from (sic)1712 to (sic)9792 ( direct cost per patient, (sic)521 to (sic)3829; and indirect cost per patient, (sic)100 to (sic)6846). Occupational hand eczema patients showed indirect costs up to 70% of total costs, mainly because of absenteeism. A large diversity in hand eczema severity was found between studies. The socio-economic burden of hand eczema is considerable, especially for more severe and/or occupational hand eczema. Absenteeism from paid work leads to a high total cost-of-illness, although disregard of presenteeism often leads to underestimation of indirect costs. Differences in included cost components, the occupational status of patients and hand eczema severity make international comparison difficult. A checklist was added to standardize the approach to cost-of-illness studies in hand eczema.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalContact Dermatitis
Issue number2
Early online dateMay-2016
Publication statusPublished - Aug-2016


  • cost-of-illness
  • hand eczema
  • health economics
  • societal costs
  • systematic review
  • LIFE


Dive into the research topics of 'Systematic review of cost-of-illness studies in hand eczema'. Together they form a unique fingerprint.

Cite this