Systems biochemistry in practice: experimenting with modelling and understanding, with regulation and control

Hans V. Westerhoff*, Malkhey Verma, Maria Nardelli, Malgorzata Adamczyk, Karen van Eunen, Evangelos Simeonidis, Barbara M. Bakker

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Biology and medicine have become 'big science', even though we may not always like this: genomics and the subsequent analysis of what the genomes encode has shown that interesting living organisms require many more than 300 gene products to interact We once thought that somewhere in this jungle of interacting macromolecules was hidden the molecule that constitutes the secret of Life, and therewith of health and disease. Now we know that, somehow, the secret of Life is the jungle of interactions. Consequently, we need to find the Rosetta Stones, i.e. interpretations of this jungle of systems biology. We need to find, perhaps convoluted, paths of understanding and intervention. Systems biochemistry is a good place to start, as it has the foothold that what goes in must come out. In the present paper, we review two strategies, which look at control and regulation. We discuss the difference between control and regulation and prove a relationship between them

Original languageEnglish
Pages (from-to)1189-1196
Number of pages8
JournalBiochemical Society Transactions
Volume38
DOIs
Publication statusPublished - Oct-2010

Keywords

  • complexity
  • control analysis
  • regulation analysis
  • systems biology
  • yeast
  • STEADY-STATE TREATMENT
  • ESCHERICHIA-COLI
  • SACCHAROMYCES-CEREVISIAE
  • METABOLIC-REGULATION
  • GLYCOLYTIC-ENZYMES
  • MATHEMATICAL-MODEL
  • ENZYMATIC CHAINS
  • CELL CYCLE
  • PATHWAY
  • FLUXES

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