Systems biology of bacterial persistence, a metabolism-driven strategy for survival

Jakub Radzikowski

Systems biology of bacterial persistence, a metabolism-driven strategy for survival

Jakub Radzikowski

Molecular Systems Biology

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

Bacterial persisters are bacteria that tolerate antibiotics and can multiply again after antibiotic treatment. They cause reccuring infections, for example tuberculosis. They are different from antibiotic-resistant bacteria, as the mechanism of antibiotic tolerance is not genetic. In this thesis, we show that these persister cells are actually much more common then previously known, and that their antibiotic tolerance is a property emerging from a general stress response to low availibilty of nutrients. The new insights into the function of bacterial persistence, seen as a metabolis-driven strategy for survival, point towards future research that could lead to their eradication.

Translated title of the contribution	Systemenbiologie van bacteriële persistentie, een metabolisme-gedreven strategie voor overleving
Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Heinemann, Matthias, Supervisor
Award date	26-Jun-2017
Place of Publication	[Groningen]
Publisher	University of Groningen
Print ISBNs	978-90-367-9865-5
Electronic ISBNs	978-90-367-9866-2
Publication status	Published - 2017

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Title and contentsFinal publisher's version, 9.45 MB
Chapter 1Final publisher's version, 4.49 MB
Chapter 2Final publisher's version, 31.7 MB
Chapter 3Final publisher's version, 9.86 MB
Chapter 4Final publisher's version, 7.66 MB
Chapter 5Final publisher's version, 8.52 MB
Chapter 6Final publisher's version, 7.99 MB
SummariesFinal publisher's version, 5.71 MB
AcknowledgementsFinal publisher's version, 2.71 MB
Complete thesisFinal publisher's version, 72.2 MB
PropositionsFinal publisher's version, 1.32 MB

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title = "Systems biology of bacterial persistence, a metabolism-driven strategy for survival",

abstract = "Bacterial persisters are bacteria that tolerate antibiotics and can multiply again after antibiotic treatment. They cause reccuring infections, for example tuberculosis. They are different from antibiotic-resistant bacteria, as the mechanism of antibiotic tolerance is not genetic. In this thesis, we show that these persister cells are actually much more common then previously known, and that their antibiotic tolerance is a property emerging from a general stress response to low availibilty of nutrients. The new insights into the function of bacterial persistence, seen as a metabolis-driven strategy for survival, point towards future research that could lead to their eradication.",

author = "Jakub Radzikowski",

year = "2017",

language = "English",

isbn = "978-90-367-9865-5",

publisher = "University of Groningen",

school = "University of Groningen",

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TY - BOOK

T1 - Systems biology of bacterial persistence, a metabolism-driven strategy for survival

AU - Radzikowski, Jakub

PY - 2017

Y1 - 2017

N2 - Bacterial persisters are bacteria that tolerate antibiotics and can multiply again after antibiotic treatment. They cause reccuring infections, for example tuberculosis. They are different from antibiotic-resistant bacteria, as the mechanism of antibiotic tolerance is not genetic. In this thesis, we show that these persister cells are actually much more common then previously known, and that their antibiotic tolerance is a property emerging from a general stress response to low availibilty of nutrients. The new insights into the function of bacterial persistence, seen as a metabolis-driven strategy for survival, point towards future research that could lead to their eradication.

AB - Bacterial persisters are bacteria that tolerate antibiotics and can multiply again after antibiotic treatment. They cause reccuring infections, for example tuberculosis. They are different from antibiotic-resistant bacteria, as the mechanism of antibiotic tolerance is not genetic. In this thesis, we show that these persister cells are actually much more common then previously known, and that their antibiotic tolerance is a property emerging from a general stress response to low availibilty of nutrients. The new insights into the function of bacterial persistence, seen as a metabolis-driven strategy for survival, point towards future research that could lead to their eradication.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-9865-5

PB - University of Groningen

CY - [Groningen]

ER -

Systems biology of bacterial persistence, a metabolism-driven strategy for survival

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