Systems biology of microbial metabolism

Matthias Heinemann*, Uwe Sauer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

102 Citations (Scopus)

Abstract

One current challenge in metabolic systems biology is to map out the regulation networks that control metabolism. From progress in this area, we conclude that non-transcriptional mechanisms (e.g. metabolite-protein interactions and protein phosphorylation) are highly relevant in actually controlling metabolic function. Furthermore, recent results highlight more functions of enzymes and metabolites than currently appreciated in genome-scale metabolic reconstructions, thereby adding another level of complexity. Combining experimental analyses and modeling efforts we are also beginning to understand how metabolic behavior emerges. Particularly, we recognize that metabolism is not simply a dull workhorse process but rather takes very active control of itself and other cellular processes, rendering true system-level understanding of metabolism possibly more difficult than for other cellular systems.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalCurrent Opinion in Microbiology
Volume13
Issue number3
DOIs
Publication statusPublished - Jun-2010

Keywords

  • ESCHERICHIA-COLI
  • BACILLUS-SUBTILIS
  • TRANSCRIPTIONAL REGULATION
  • MOONLIGHTING PROTEINS
  • SACCHAROMYCES-CEREVISIAE
  • CATABOLITE REPRESSION
  • GLYCOLYTIC-ENZYMES
  • REGULATORY NETWORK
  • GENE-EXPRESSION
  • E. COLI

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