Taking the STING out of CIN

Anouk van den Brink; Floris Foijer

doi:10.1016/j.trecan.2023.09.010

Taking the STING out of CIN

Anouk van den Brink, Floris Foijer^*

^*Corresponding author for this work

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Abstract

Chromosomal instability (CIN), a hallmark of cancer, promotes cell-intrinsic inflammatory signaling. Although inflammation is generally considered tumor-suppressive, this relationship is more complex in cancers with CIN. We discuss new findings by Li et al. that can explain how cancer cells with CIN tolerate, adopt, and rewire the CIN-induced inflammatory response to fuel tumorigenesis.

Original language	English
Pages (from-to)	992-994
Number of pages	3
Journal	Trends in cancer
Volume	9
Issue number	12
Early online date	6-Oct-2023
DOIs	https://doi.org/10.1016/j.trecan.2023.09.010
Publication status	Published - Dec-2023

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@article{9bbc694f588f4967bba654bfb5a43499,

title = "Taking the STING out of CIN",

abstract = "Chromosomal instability (CIN), a hallmark of cancer, promotes cell-intrinsic inflammatory signaling. Although inflammation is generally considered tumor-suppressive, this relationship is more complex in cancers with CIN. We discuss new findings by Li et al. that can explain how cancer cells with CIN tolerate, adopt, and rewire the CIN-induced inflammatory response to fuel tumorigenesis.",

author = "{van den Brink}, Anouk and Floris Foijer",

year = "2023",

month = dec,

doi = "10.1016/j.trecan.2023.09.010",

language = "English",

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journal = "Trends in cancer",

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T1 - Taking the STING out of CIN

AU - van den Brink, Anouk

AU - Foijer, Floris

PY - 2023/12

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N2 - Chromosomal instability (CIN), a hallmark of cancer, promotes cell-intrinsic inflammatory signaling. Although inflammation is generally considered tumor-suppressive, this relationship is more complex in cancers with CIN. We discuss new findings by Li et al. that can explain how cancer cells with CIN tolerate, adopt, and rewire the CIN-induced inflammatory response to fuel tumorigenesis.

AB - Chromosomal instability (CIN), a hallmark of cancer, promotes cell-intrinsic inflammatory signaling. Although inflammation is generally considered tumor-suppressive, this relationship is more complex in cancers with CIN. We discuss new findings by Li et al. that can explain how cancer cells with CIN tolerate, adopt, and rewire the CIN-induced inflammatory response to fuel tumorigenesis.

U2 - 10.1016/j.trecan.2023.09.010

DO - 10.1016/j.trecan.2023.09.010

M3 - Article

C2 - 37806895

SN - 2405-8025

VL - 9

SP - 992

EP - 994

JO - Trends in cancer

JF - Trends in cancer

IS - 12

ER -

Taking the STING out of CIN

Abstract

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