Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

A. F. Y. Al Hadithy; S. A. Ivanova; P. Pechlivanoglou; A. Semke; O. Fedorenko; E. Kornetova; L. Ryadovaya; J. R. B. J. Brouwers; B. Wilffert; R. Bruggeman; A. J. M. Loonen

doi:10.1016/j.pnpbp.2009.01.010

Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

A. F. Y. Al Hadithy^*
, S. A. Ivanova
, P. Pechlivanoglou
, A. Semke
, O. Fedorenko
, E. Kornetova
, L. Ryadovaya
, J. R. B. J. Brouwers
, B. Wilffert
, R. Bruggeman
, A. J. M. Loonen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians.

Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia.

Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use).

Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt.

Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data. (C) 2009 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	475-481
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology & Biological Psychiatry
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.pnpbp.2009.01.010
Publication status	Published - 30-Apr-2009

Keywords

DRD3
Extrapyramidal syndromes
HTR2A
HTR2C
Pharmacogenetics
Tardive dyskinesia
DOPAMINE D3 RECEPTOR
CHRONIC-SCHIZOPHRENIA
MOVEMENT-DISORDERS
SUB-SYNDROMES
SEROTONIN 2C
RISK-FACTORS
ASSOCIATION
ETHNICITY
PHARMACOGENETICS
ANTIPSYCHOTICS

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10.1016/j.pnpbp.2009.01.010

Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphismsFinal publisher's version, 198 KBLicence: Taverne

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Al Hadithy, A. F. Y., Ivanova, S. A., Pechlivanoglou, P., Semke, A., Fedorenko, O., Kornetova, E., Ryadovaya, L., Brouwers, J. R. B. J., Wilffert, B., Bruggeman, R., & Loonen, A. J. M. (2009). Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(3), 475-481. https://doi.org/10.1016/j.pnpbp.2009.01.010

@article{2bd693ffdb7c48cfaba71dffd7ced054,

title = "Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia",

abstract = "Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians.Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia.Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use).Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt.Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data. (C) 2009 Elsevier Inc. All rights reserved.",

keywords = "DRD3, Extrapyramidal syndromes, HTR2A, HTR2C, Pharmacogenetics, Tardive dyskinesia, DOPAMINE D3 RECEPTOR, CHRONIC-SCHIZOPHRENIA, MOVEMENT-DISORDERS, SUB-SYNDROMES, SEROTONIN 2C, RISK-FACTORS, ASSOCIATION, ETHNICITY, PHARMACOGENETICS, ANTIPSYCHOTICS",

author = "\{Al Hadithy\}, \{A. F. Y.\} and Ivanova, \{S. A.\} and P. Pechlivanoglou and A. Semke and O. Fedorenko and E. Kornetova and L. Ryadovaya and Brouwers, \{J. R. B. J.\} and B. Wilffert and R. Bruggeman and Loonen, \{A. J. M.\}",

year = "2009",

month = apr,

day = "30",

doi = "10.1016/j.pnpbp.2009.01.010",

language = "English",

volume = "33",

pages = "475--481",

journal = "Progress in Neuro-Psychopharmacology \& Biological Psychiatry",

issn = "0278-5846",

publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

number = "3",

}

Al Hadithy, AFY, Ivanova, SA, Pechlivanoglou, P, Semke, A, Fedorenko, O, Kornetova, E, Ryadovaya, L, Brouwers, JRBJ, Wilffert, B, Bruggeman, R & Loonen, AJM 2009, 'Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia', Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 33, no. 3, pp. 475-481. https://doi.org/10.1016/j.pnpbp.2009.01.010

TY - JOUR

T1 - Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

AU - Al Hadithy, A. F. Y.

AU - Ivanova, S. A.

AU - Pechlivanoglou, P.

AU - Semke, A.

AU - Fedorenko, O.

AU - Kornetova, E.

AU - Ryadovaya, L.

AU - Brouwers, J. R. B. J.

AU - Wilffert, B.

AU - Bruggeman, R.

AU - Loonen, A. J. M.

PY - 2009/4/30

Y1 - 2009/4/30

N2 - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians.Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia.Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use).Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt.Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data. (C) 2009 Elsevier Inc. All rights reserved.

AB - Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians.Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and Ser9Gly (DRD3), -1438G>A (HTR2A), and Cys23ser (HTR2C) polymorphisms in Russian psychiatric inpatients from Tomsk, Siberia.Methods: In total, 146 subjects were included. Standard protocols were applied for genotyping. TDof and TDlt were assessed with AIMS items 1-4 and 5-7, respectively. Two-part model, logistic and log-normal regression analyses were applied to assess different variables (e.g., allele-carriership status, age, gender, and medication use).Results: TDlt, but not TDof, exhibited an association with Ser9Gly and Cys23ser (with 9Gly and 23Ser alleles exhibiting opposite effects). However, -1438G>A was not associated with TDof and Dlt.Conclusions: This is the first pharmacogenetic report on tardive dyskinesia in Russians. Subject to further replication, our findings extend and support the available data. (C) 2009 Elsevier Inc. All rights reserved.

KW - DRD3

KW - Extrapyramidal syndromes

KW - HTR2A

KW - HTR2C

KW - Pharmacogenetics

KW - Tardive dyskinesia

KW - DOPAMINE D3 RECEPTOR

KW - CHRONIC-SCHIZOPHRENIA

KW - MOVEMENT-DISORDERS

KW - SUB-SYNDROMES

KW - SEROTONIN 2C

KW - RISK-FACTORS

KW - ASSOCIATION

KW - ETHNICITY

KW - PHARMACOGENETICS

KW - ANTIPSYCHOTICS

U2 - 10.1016/j.pnpbp.2009.01.010

DO - 10.1016/j.pnpbp.2009.01.010

M3 - Article

SN - 0278-5846

VL - 33

SP - 475

EP - 481

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

IS - 3

ER -

Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

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Keywords

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