Targeted Imaging and Therapeutic Technologies in Neuroregeneration

Jelena M. Janjic, Mihaly Balogh, Sandeep Kumarena Reddy Adena, Amanda Fitzpatrick, John A. Pollock, Vijay Gorantla, Andrew J. Shepherd

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Extremity injuries are less likely to be fatal than head, chest, and abdominal wounds; however, they can be severely disabling. Peripheral nerve injury (PNI) can result from trauma (lacerations, penetrating injury, stretching, ischemia or crushing trauma and fractures, and gunshot wounds), repetitive compression (tunnel syndromes), or iatrogenic causes (orthopedic, plastic, neurosurgical or other surgical procedures such as oncologic resection). Nerve regeneration is an essential process needed for the recovery of function. However, our understanding of this process is still rather limited, and access to successful personalized regeneration supportive treatment is lacking. This chapter focuses on surveying new technological advances such as targeted nanoimaging and immunomodulation in support of neuroregeneration following peripheral injuries. Specifically, we highlight new nanotechnology advances in targeted cell tracking and imaging, as well as targeted drug delivery and cellular therapeutics. Though most of this work is preclinical, we hope that these advances drive the development of novel, safe and effective clinical solutions.
Original languageEnglish
Title of host publicationReconstructive Transplantation and Regenerative Medicine
EditorsVijay Gorantla, Fatih Zor, Jelena M. Janijc
Place of PublicationBoca Raton
PublisherCRC Press, Taylor and Francis Group
Number of pages20
ISBN (Electronic)9780429260179
ISBN (Print) 9780367202088 (hbk), 9781032116761 (pbk)
Publication statusPublished - 2022

Publication series

NameGene and Cell Therapy Series
PublisherCRC Press

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