Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

Jiaying Han, Jing Sun, Shanshan Song, Leonie Beljaars, Geny M M Groothuis, Hjalmar Permentier, Rainer Bischoff, Gyorgy B Halmos, Cornelia J Verhoeven, Erika R Amstalden van Hove, Peter Horvatovich*, Angela Casini

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins avß3 in human cancer tissues.

Original languageEnglish
Pages (from-to)5941-5944
Number of pages4
JournalChemical communications (Cambridge, England)
Volume56
Issue number44
Early online date29-Apr-2020
DOIs
Publication statusPublished - 4-Jun-2020

Keywords

  • HIGH-SPATIAL-RESOLUTION
  • TRANSMISSION GEOMETRY
  • SPECTROMETRY
  • RUTHENIUM
  • ALPHA-V-BETA-3
  • DESORPTION

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