Targeting liposomes to endothelial cells in inflammatory diseases

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    The endothelium covers the vascular wall of all blood vessels in the body and comprises 1013 endothelial cells (ECs) in an adult (1). Their excellent accessibility for drugs present in the systemic circulation and their involvement in a large variety of physiological and pathophysiological processes make ECs ideal targets for targeted liposome-mediated drug delivery. The heterogeneity of the endothelium with respect to appearance and function allows for drug delivery approaches that are either organ and/or disease specific. Despite these features, research on liposome-mediated drug delivery to ECs is limited. This is undoubtedly related to the fact that ECs are generally refractory to liposome uptake (2) and that the use of specific targeting devices are a prerequisite for liposome uptake by selected cell subsets.

    Original languageEnglish
    Title of host publicationLiposome Technology
    Subtitle of host publicationInteractions of Liposomes with the Biological Milieu
    PublisherCRC Press
    Number of pages24
    ISBN (Electronic)9780849397288
    ISBN (Print)9780849397257
    Publication statusPublished - 1-Jan-2006

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