Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library

Piotr Nowak, Mathieu Colomb-Delsuc, Sijbren Otto, Jianwei Li

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32 Citations (Scopus)
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Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.

Original languageEnglish
Pages (from-to)10965-10969
Number of pages5
JournalJournal of the American Chemical Society
Issue number34
Publication statusPublished - 2-Sept-2015

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