Temporal Relationship Between Subclinical Atrial Fibrillation and Embolic Events

Michela Brambatti, Stuart J. Connolly, Michael R. Gold, Carlos A. Morillo, Alessandro Capucci, Carmine Muto, Chu P. Lau, Isabelle C. Van Gelder, Stefan H. Hohnloser, Mark Carlson, Eric Fain, Juliet Nakamya, Georges H. Mairesse, Marta Halytska, Wei Q. Deng, Carsten W. Israel, Jeff S. Healey*, ASSERT Investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

428 Citations (Scopus)

Abstract

Background-Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated with an increased risk of stroke; however, there is limited understanding of their temporal relationship.

Methods and Results-The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) enrolled 2580 pacemaker and defibrillator patients aged >= 65 years with a history of hypertension but without a history of atrial fibrillation. Pacemakers and implantable cardioverter-defibrillators precisely logged the time and duration of all episodes of SCAF and recorded electrograms that were adjudicated by experts. We examined the temporal relationship between SCAF >6 minutes in duration and stroke or systemic embolism. Of 51 patients who experienced stroke or systemic embolism during follow-up, 26 (51%) had SCAF. In 18 patients (35%), SCAF was detected before stroke or systemic embolism. However, only 4 patients (8%) had SCAF detected within 30 days before stroke or systemic embolism, and only 1 of these 4 patients was experiencing SCAF at the time of the stroke. In the 14 patients with SCAF detected >30 days before stroke or systemic embolism, the most recent episode occurred at a median interval of 339 days (25th to 75th percentile, 211-619) earlier. Eight patients (16%) had SCAF detected only after their stroke, despite continuous monitoring for a median duration of 228 days (25th to 75th percentile, 202-719) before their event.

Conclusions-Although SCAF is associated with an increased risk of stroke and embolism, very few patients had SCAF in the month before their event.

Original languageEnglish
Pages (from-to)2094-2099
Number of pages6
JournalCirculation
Volume129
Issue number21
DOIs
Publication statusPublished - 27-May-2014

Keywords

  • arrhythmia
  • pacemaker
  • stroke
  • ORAL ANTICOAGULATION
  • SUBGROUP ANALYSIS
  • RISK FACTOR
  • STROKE
  • TRIAL
  • FLUTTER
  • RHYTHM
  • THROMBOEMBOLISM
  • CARDIOVERSION
  • PREVALENCE

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