Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

Nelleke Tolboom; Maqsood Yaqub; Ronald Boellaard; Gert Luurtsema; Albert D. Windhorst; Philip Scheltens; Adriaan A. Lammertsma; Bart N. M. van Berckel

doi:10.1007/s00259-009-1129-6

Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

Nelleke Tolboom^*, Maqsood Yaqub, Ronald Boellaard, Gert Luurtsema, Albert D. Windhorst, Philip Scheltens, Adriaan A. Lammertsma, Bart N. M. van Berckel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.

Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.

Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.

Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.

Original language	English
Pages (from-to)	1629-1638
Number of pages	10
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	36
Issue number	10
DOIs	https://doi.org/10.1007/s00259-009-1129-6
Publication status	Published - Oct-2009
Externally published	Yes

Keywords

Pittsburgh compound B
PIB
Arterial sampling
Cerebellum
Parametric images
Amyloid
PET
PITTSBURGH COMPOUND-B
REFERENCE TISSUE MODEL
AMYLOID DEPOSITION
SENILE PLAQUES
HUMAN BRAIN
BINDING
NEURORECEPTOR
CEREBELLUM
RECEPTOR

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title = "Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease",

abstract = "Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.",

keywords = "Pittsburgh compound B, PIB, Arterial sampling, Cerebellum, Parametric images, Amyloid, PET, PITTSBURGH COMPOUND-B, REFERENCE TISSUE MODEL, AMYLOID DEPOSITION, SENILE PLAQUES, HUMAN BRAIN, BINDING, NEURORECEPTOR, CEREBELLUM, RECEPTOR",

author = "Nelleke Tolboom and Maqsood Yaqub and Ronald Boellaard and Gert Luurtsema and Windhorst, {Albert D.} and Philip Scheltens and Lammertsma, {Adriaan A.} and {van Berckel}, {Bart N. M.}",

year = "2009",

month = oct,

doi = "10.1007/s00259-009-1129-6",

language = "English",

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journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

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TY - JOUR

T1 - Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

AU - Tolboom, Nelleke

AU - Yaqub, Maqsood

AU - Boellaard, Ronald

AU - Luurtsema, Gert

AU - Windhorst, Albert D.

AU - Scheltens, Philip

AU - Lammertsma, Adriaan A.

AU - van Berckel, Bart N. M.

PY - 2009/10

Y1 - 2009/10

N2 - Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.

AB - Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.

KW - Pittsburgh compound B

KW - PIB

KW - Arterial sampling

KW - Cerebellum

KW - Parametric images

KW - Amyloid

KW - PET

KW - PITTSBURGH COMPOUND-B

KW - REFERENCE TISSUE MODEL

KW - AMYLOID DEPOSITION

KW - SENILE PLAQUES

KW - HUMAN BRAIN

KW - BINDING

KW - NEURORECEPTOR

KW - CEREBELLUM

KW - RECEPTOR

U2 - 10.1007/s00259-009-1129-6

DO - 10.1007/s00259-009-1129-6

M3 - Article

SN - 1619-7070

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JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 10

ER -

Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer's disease

Abstract

Keywords

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