The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers

U. Gehring*, J. C. de Jongste, M. Kerkhof, M. Oldewening, D. Postma, R. T. van Strien, A. H. Wijga, S. M. Willers, A. Wolse, J. Gerritsen, H. A. Smit, B. Brunekreef

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)

Abstract

Background: Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite-impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life. Methods: High-risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergenimpermeable (n = 416) and placebo mattress covers (n = 394) or no intervention (n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper-responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens. Results: At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms. Conclusion: Early intervention with mite-impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalAllergy
Volume67
Issue number2
DOIs
Publication statusPublished - Feb-2012

Keywords

  • allergens
  • allergy
  • asthma
  • house dust mite
  • intervention
  • HOUSE-DUST MITE
  • ASTHMA PRIMARY PREVENTION
  • PET ALLERGEN LEVELS
  • CHILDHOOD ASTHMA
  • CONTROLLED-TRIAL
  • EARLY-LIFE
  • BRONCHIAL HYPERREACTIVITY
  • MANCHESTER ASTHMA
  • BIRTH COHORT
  • EXPOSURE

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